Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia
Introduction: neonates with high birth weight are at increased risk of birth complications and long term health problems. An unexplored factor during gestation is the level of circulating fatty acids. Materials and methods: prospective study where women were studied during pregnancy until delivery....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Sello Editorial Lugones
2022-07-01
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| Series: | Revista de la Sociedad Argentina de Diabetes |
| Subjects: | |
| Online Access: | https://revistasad.com/index.php/diabetes/article/view/515 |
| _version_ | 1828186793402433536 |
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| author | Marina Inés Curriá María Jimena Cerar Gabriela Rovira Melina Saban Glenda Ernst Adriana L. Burgueño |
| author_facet | Marina Inés Curriá María Jimena Cerar Gabriela Rovira Melina Saban Glenda Ernst Adriana L. Burgueño |
| author_sort | Marina Inés Curriá |
| collection | DOAJ |
| description | Introduction: neonates with high birth weight are at increased risk of birth complications and long term health problems. An unexplored factor during gestation is the level of circulating fatty acids.
Materials and methods: prospective study where women were studied during pregnancy until delivery. Anthropometric variables and free fatty acid measurements were analyzed between 24-28 weeks of gestation.
Results: we included 27 patients, of whom 4 (13.8%) gave birth to macrosomic newborns. Patients were grouped according to pre-pregnancy mass index (BMI) into normal weight and overweight or obese. Macrosomic neonates corresponded to the group of overweight and obese mothers, who also presented a signi cant increase in free fatty acid levels (2067 uM, ICC: 947,5-1590 vs 1212 uM, ICC: 13367-2247; p<0.05) was found in the obese and overweight group. Basal and post oral glucose tolerance test showed no differences, Multivariate analysis showed that being obese or overweight at the beginning of pregnancy results in an OR of free fatty acids 1,0023 (95%CI: 1,0000-1,0046), while oral glucose tolerance test presented an OR: 1,0186 (95%CI: 0,9645-1,0756).
Conclusions: the results show the role of pre-gestational BMI on the risk of having macrosomic children, confirming the need to improve the nutritional status of women before and during pregnancy. |
| first_indexed | 2024-04-12T07:24:57Z |
| format | Article |
| id | doaj.art-73436990b31a4ce5b49d1665b91a4dfd |
| institution | Directory Open Access Journal |
| issn | 0325-5247 2346-9420 |
| language | Spanish |
| last_indexed | 2024-04-12T07:24:57Z |
| publishDate | 2022-07-01 |
| publisher | Sello Editorial Lugones |
| record_format | Article |
| series | Revista de la Sociedad Argentina de Diabetes |
| spelling | doaj.art-73436990b31a4ce5b49d1665b91a4dfd2022-12-22T03:42:13ZspaSello Editorial LugonesRevista de la Sociedad Argentina de Diabetes0325-52472346-94202022-07-01562576210.47196/diab.v56i2.515439Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomiaMarina Inés Curriá0María Jimena Cerar1Gabriela Rovira2Melina Saban3Glenda Ernst4Adriana L. Burgueño5Hospital Británico, Ciudad Autónoma de Buenos Aires, ArgentinaHospital Británico de Buenos Aires, Ciudad Autónoma de Buenos Aires, ArgentinaHospital Británico, Ciudad Autónoma de Buenos Aires, ArgentinaHospital Británico de Buenos Aires, Ciudad Autónoma de Buenos Aires, ArgentinaHospital Británico, Ciudad Autónoma de Buenos Aires, ArgentinaUniversidad Católica Argentina (UCA), Ciudad Autónoma de Buenos Aires, ArgentinaIntroduction: neonates with high birth weight are at increased risk of birth complications and long term health problems. An unexplored factor during gestation is the level of circulating fatty acids. Materials and methods: prospective study where women were studied during pregnancy until delivery. Anthropometric variables and free fatty acid measurements were analyzed between 24-28 weeks of gestation. Results: we included 27 patients, of whom 4 (13.8%) gave birth to macrosomic newborns. Patients were grouped according to pre-pregnancy mass index (BMI) into normal weight and overweight or obese. Macrosomic neonates corresponded to the group of overweight and obese mothers, who also presented a signi cant increase in free fatty acid levels (2067 uM, ICC: 947,5-1590 vs 1212 uM, ICC: 13367-2247; p<0.05) was found in the obese and overweight group. Basal and post oral glucose tolerance test showed no differences, Multivariate analysis showed that being obese or overweight at the beginning of pregnancy results in an OR of free fatty acids 1,0023 (95%CI: 1,0000-1,0046), while oral glucose tolerance test presented an OR: 1,0186 (95%CI: 0,9645-1,0756). Conclusions: the results show the role of pre-gestational BMI on the risk of having macrosomic children, confirming the need to improve the nutritional status of women before and during pregnancy.https://revistasad.com/index.php/diabetes/article/view/515ácidos grasos libresembarazomacrosomía |
| spellingShingle | Marina Inés Curriá María Jimena Cerar Gabriela Rovira Melina Saban Glenda Ernst Adriana L. Burgueño Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia Revista de la Sociedad Argentina de Diabetes ácidos grasos libres embarazo macrosomía |
| title | Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia |
| title_full | Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia |
| title_fullStr | Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia |
| title_full_unstemmed | Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia |
| title_short | Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia |
| title_sort | relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia |
| topic | ácidos grasos libres embarazo macrosomía |
| url | https://revistasad.com/index.php/diabetes/article/view/515 |
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