T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers
<p>Abstract</p> <p>Background</p> <p>Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment.</p> <p>Methods</p> <p>Thirty four EC were studied. The slope of CD4 c...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-06-01
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| Series: | AIDS Research and Therapy |
| Subjects: | |
| Online Access: | http://www.aidsrestherapy.com/content/8/1/20 |
| _version_ | 1819203546187300864 |
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| author | Côté Pierre Thomas Réjean Routy Jean-Pierre Boulet Salix Tsoukas Christos M Kamya Philomena Boulassel Mohamed-Rachid Lessard Bernard Kaul Rupert Ostrowski Mario Kovacs Colin Tremblay Cecile L Bernard Nicole F |
| author_facet | Côté Pierre Thomas Réjean Routy Jean-Pierre Boulet Salix Tsoukas Christos M Kamya Philomena Boulassel Mohamed-Rachid Lessard Bernard Kaul Rupert Ostrowski Mario Kovacs Colin Tremblay Cecile L Bernard Nicole F |
| author_sort | Côté Pierre |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment.</p> <p>Methods</p> <p>Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38<sup>+</sup>HLA-DR<sup>+</sup>CD8<sup>+ </sup>T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls.</p> <p>Results</p> <p>Compared to HIV uninfected subjects, EC had higher percentages of CD38<sup>+</sup>HLA-DR<sup>+</sup>CD8<sup>+ </sup>T cells (p < 0.001) that was lower than that observed in progressors (p < 0.01). Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets with stable/increasing versus declining CD4 counts.</p> <p>Conclusions</p> <p>Elevated immune activation in ECs is not associated with a faster rate of CD4 decline</p> |
| first_indexed | 2024-12-23T04:21:38Z |
| format | Article |
| id | doaj.art-73457a7e948a437ba6e68d85f7a4ae46 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-23T04:21:38Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-73457a7e948a437ba6e68d85f7a4ae462022-12-21T18:00:14ZengBMCAIDS Research and Therapy1742-64052011-06-01812010.1186/1742-6405-8-20T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite ControllersCôté PierreThomas RéjeanRouty Jean-PierreBoulet SalixTsoukas Christos MKamya PhilomenaBoulassel Mohamed-RachidLessard BernardKaul RupertOstrowski MarioKovacs ColinTremblay Cecile LBernard Nicole F<p>Abstract</p> <p>Background</p> <p>Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment.</p> <p>Methods</p> <p>Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38<sup>+</sup>HLA-DR<sup>+</sup>CD8<sup>+ </sup>T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls.</p> <p>Results</p> <p>Compared to HIV uninfected subjects, EC had higher percentages of CD38<sup>+</sup>HLA-DR<sup>+</sup>CD8<sup>+ </sup>T cells (p < 0.001) that was lower than that observed in progressors (p < 0.01). Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets with stable/increasing versus declining CD4 counts.</p> <p>Conclusions</p> <p>Elevated immune activation in ECs is not associated with a faster rate of CD4 decline</p>http://www.aidsrestherapy.com/content/8/1/20HIV infectionElite controllersactivation markersCD4 count change |
| spellingShingle | Côté Pierre Thomas Réjean Routy Jean-Pierre Boulet Salix Tsoukas Christos M Kamya Philomena Boulassel Mohamed-Rachid Lessard Bernard Kaul Rupert Ostrowski Mario Kovacs Colin Tremblay Cecile L Bernard Nicole F T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers AIDS Research and Therapy HIV infection Elite controllers activation markers CD4 count change |
| title | T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers |
| title_full | T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers |
| title_fullStr | T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers |
| title_full_unstemmed | T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers |
| title_short | T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers |
| title_sort | t cell activation does not drive cd4 decline in longitudinally followed hiv infected elite controllers |
| topic | HIV infection Elite controllers activation markers CD4 count change |
| url | http://www.aidsrestherapy.com/content/8/1/20 |
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