Comprehensive Physicochemical Characterization, In Vitro Membrane Permeation, and In Vitro Human Skin Cell Culture of a Novel TOPK Inhibitor, HI-TOPK-032

Comprehensive Physicochemical Characterization, In Vitro Membrane Permeation, and In Vitro Human Skin Cell Culture of a Novel TOPK Inhibitor, HI-TOPK-032

Nonmelanoma skin cancers (NMSC) are the most common skin cancers, and about 5.4 million people are diagnosed each year in the United States. A newly developed T-lymphokine-activated killer cell-originated protein kinase (TOPK) inhibitor, HI-TOPK-032, is effective in suppressing colon cancer cell gro...

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Bibliographic Details
Main Authors: Basanth Babu Eedara, Bhagyashree Manivannan, Wafaa Alabsi, Bo Sun, Clara Curiel-Lewandrowski, Tianshun Zhang, Ann M. Bode, Heidi M. Mansour
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
NMSC
Strat-M
HaCaT cell line
NHEK cells
cell viability
TEER
Online Access:https://www.mdpi.com/1422-0067/24/21/15515

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