Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model

Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model

Synaptic loss in Alzheimer's disease (AD) is strongly correlated with cognitive impairment. Accumulating evidence indicates that amyloid pathology leads to synaptic degeneration and mitochondrial damage in AD. However, it remains unclear whether synapses and presynaptic mitochondria are differe...

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Bibliographic Details
Main Authors: Na-young Seo, Gyu Hyun Kim, Jeong Eun Noh, Ji Won Shin, Chan Hee Lee, Kea Joo Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroanatomy
Subjects:
Alzheimer's disease
5xFAD
synapse
mitochondria
cortex
electron microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2021.690168/full

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