A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow
We report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow. A patient with additional chromosomes X and 5 with a Philadelphia chromosome has not been reported previously. However, no abnormal karyotype was ob...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2010-12-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-14632 |
| _version_ | 1797917055130796032 |
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| author | Burak Durmaz Asude Alpman Durmaz Emin Karaca Güray Saydam Özgür Çoğulu Ferda Özkınay |
| author_facet | Burak Durmaz Asude Alpman Durmaz Emin Karaca Güray Saydam Özgür Çoğulu Ferda Özkınay |
| author_sort | Burak Durmaz |
| collection | DOAJ |
| description | We report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow. A patient with additional chromosomes X and 5 with a Philadelphia chromosome has not been reported previously. However, no abnormal karyotype was obtained from the lymphocytes in our patient, and he did not have the characteristics of Klinefelter syndrome. He achieved a complete remission with IDA-FLAG and dasatinib therapy. The mechanism of trisomy 5 or any other chromosomal aneuploidy in the pathogenesis of leukemogenesis remains unclear. Further studies involving the genes affected by this karyotype and their products may lead to strategies to further increase the understanding of drug-resistant acute lymphoblastic leukemia and may represent the next frontier in the targeted therapy of those patients. |
| first_indexed | 2024-04-10T13:07:12Z |
| format | Article |
| id | doaj.art-7347e378128840fea97171dcd325f68e |
| institution | Directory Open Access Journal |
| issn | 1300-7777 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T13:07:12Z |
| publishDate | 2010-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-7347e378128840fea97171dcd325f68e2023-02-15T16:12:56ZengGalenos Publishing HouseTurkish Journal of Hematology1300-77771308-52632010-12-012704299302A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrowBurak DurmazAsude Alpman DurmazEmin KaracaGüray SaydamÖzgür ÇoğuluFerda ÖzkınayWe report herein a very rare case of acute lymphoblastic leukemia having a chromosomal constitution of 48,XY,+X,+5,t(9;22)(q34;q11) in the bone marrow. A patient with additional chromosomes X and 5 with a Philadelphia chromosome has not been reported previously. However, no abnormal karyotype was obtained from the lymphocytes in our patient, and he did not have the characteristics of Klinefelter syndrome. He achieved a complete remission with IDA-FLAG and dasatinib therapy. The mechanism of trisomy 5 or any other chromosomal aneuploidy in the pathogenesis of leukemogenesis remains unclear. Further studies involving the genes affected by this karyotype and their products may lead to strategies to further increase the understanding of drug-resistant acute lymphoblastic leukemia and may represent the next frontier in the targeted therapy of those patients.http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-14632ALLX chromosomechromosome 5Philadelphia chromosome |
| spellingShingle | Burak Durmaz Asude Alpman Durmaz Emin Karaca Güray Saydam Özgür Çoğulu Ferda Özkınay A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow Turkish Journal of Hematology ALL X chromosome chromosome 5 Philadelphia chromosome |
| title | A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow |
| title_full | A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow |
| title_fullStr | A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow |
| title_full_unstemmed | A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow |
| title_short | A case of acute lymphoblastic leukemia with additional chromosomes X and 5 associated with a Philadelphia chromosome in the bone marrow |
| title_sort | case of acute lymphoblastic leukemia with additional chromosomes x and 5 associated with a philadelphia chromosome in the bone marrow |
| topic | ALL X chromosome chromosome 5 Philadelphia chromosome |
| url | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-14632 |
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