Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway

Regulation of type I interferon signature by VGLL3 in the fibroblast-like synoviocytes of rheumatoid arthritis patients via targeting the Hippo pathway

Abstract Background The upregulation of interferon (IFN)-stimulated genes induced by type I IFNs (namely type I IFN signature) in rheumatoid arthritis (RA) patients had implications in early diagnosis and prediction of therapy responses. However, factors that modulate the type I IFN signature in RA...

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Bibliographic Details
Main Authors: Yu Du, Ran Cui, Na Tian, Miao Chen, Xian-Long Zhang, Sheng-Ming Dai
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Interferon beta
Type I interferon signature
Hippo pathway
Online Access:https://doi.org/10.1186/s13075-022-02880-0

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