Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

Abstract SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-spike protein IgG seroconversion has not been define...

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Bibliographic Details
Main Authors: Nicholas S. Giroux, Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, Ergang Wang, Rui Xi, Shree Bose, Tomer Rotstein, Bradly P. Nicholson, Tianyi Chen, Ricardo Henao, Gregory D. Sempowski, Thomas N. Denny, Maria Iglesias De Ussel, Lisa L. Satterwhite, Emily R. Ko, Geoffrey S. Ginsburg, Bryan D. Kraft, Ephraim L. Tsalik, Xiling Shen, Christopher W. Woods
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15668-8

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