Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19
Abstract Aim In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Method Patients (≥65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-022-03059-7 |
| _version_ | 1818264250352664576 |
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| author | Uğur Önal Muhammet Gülhan Neşe Demirci Ahmet Özden Nazlı Erol Sema Işık Sedat Gülten Fatma Atalay Nilay Çöplü |
| author_facet | Uğur Önal Muhammet Gülhan Neşe Demirci Ahmet Özden Nazlı Erol Sema Işık Sedat Gülten Fatma Atalay Nilay Çöplü |
| author_sort | Uğur Önal |
| collection | DOAJ |
| description | Abstract Aim In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Method Patients (≥65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center were recorded retrospectively. A p value less than 0.05 was considered significant. Ethical committee approval was given from the Bolu University with decision number 2020/176. Results There were a total of 100 patients (44% female). In-hospital mortality was recorded as 7%. In univariate analysis for 1 month mortality, diabetes mellitus (p = 0.038), leucocyte count (p = 0.005), neutrophile count (p = 0.02), neutrophile-to-lymphocyte ratio (NLR) (p < 0.001), thrombocyte-to-lymphocyte ratio (TLR) (p = 0.001), C-reactive protein (CRP) (p = 0.002), lactate dehydrogenase (LDH) (p = 0.001), sequential organ failure assessment (SOFA) score (p = 0.001) and qSOFA score (p = 0.002) were found as independent risk factors. On admission, one point increase of NLR (p = 0.014, odds ratio (OR) = 1.371, 95% CI = 1.067–1.761) and one point increase of LDH (p = 0.047, OR = 1.011, 95% CI = 1.001–1.023) were associated with mortality on day 30 according to logistic regression analysis. The cut-off values were found as > 7.8 for NLR (83.33% sensitivity, 97.7% specificity) and > 300 U/L for LDH (100% sensitivity, 79.31% specificity) regarding the prediction of 30-day mortality. Conclusion In order to improve clinical management and identify the geriatric patients with COVID-19 who have high risk for mortality, NLR and LDH levels on admission might be useful prognostic tools. |
| first_indexed | 2024-12-12T19:31:55Z |
| format | Article |
| id | doaj.art-734bf812367e419e979d85500d154248 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-12T19:31:55Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-734bf812367e419e979d85500d1542482022-12-22T00:14:24ZengBMCBMC Geriatrics1471-23182022-04-012211610.1186/s12877-022-03059-7Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19Uğur Önal0Muhammet Gülhan1Neşe Demirci2Ahmet Özden3Nazlı Erol4Sema Işık5Sedat Gülten6Fatma Atalay7Nilay Çöplü8Department of Infectious Diseases and Clinical Microbiology, Kastamonu Training and Research HospitalDepartment of Infectious Diseases and Clinical Microbiology, Kastamonu Training and Research HospitalDepartment of Infectious Diseases and Clinical Microbiology, Kastamonu Training and Research HospitalDepartment of Radiology, Kastamonu Training and Research HospitalDepartment of Pulmonary Diseases, Kastamonu Training and Research HospitalDepartment of Internal Medicine, Kastamonu Training and Research HospitalDepartment of Biochemistry, Kastamonu Training and Research HospitalDepartment of Ear, Nose and Throat, Kastamonu Training and Research HospitalDepartment of Microbiology, Kastamonu Training and Research HospitalAbstract Aim In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Method Patients (≥65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center were recorded retrospectively. A p value less than 0.05 was considered significant. Ethical committee approval was given from the Bolu University with decision number 2020/176. Results There were a total of 100 patients (44% female). In-hospital mortality was recorded as 7%. In univariate analysis for 1 month mortality, diabetes mellitus (p = 0.038), leucocyte count (p = 0.005), neutrophile count (p = 0.02), neutrophile-to-lymphocyte ratio (NLR) (p < 0.001), thrombocyte-to-lymphocyte ratio (TLR) (p = 0.001), C-reactive protein (CRP) (p = 0.002), lactate dehydrogenase (LDH) (p = 0.001), sequential organ failure assessment (SOFA) score (p = 0.001) and qSOFA score (p = 0.002) were found as independent risk factors. On admission, one point increase of NLR (p = 0.014, odds ratio (OR) = 1.371, 95% CI = 1.067–1.761) and one point increase of LDH (p = 0.047, OR = 1.011, 95% CI = 1.001–1.023) were associated with mortality on day 30 according to logistic regression analysis. The cut-off values were found as > 7.8 for NLR (83.33% sensitivity, 97.7% specificity) and > 300 U/L for LDH (100% sensitivity, 79.31% specificity) regarding the prediction of 30-day mortality. Conclusion In order to improve clinical management and identify the geriatric patients with COVID-19 who have high risk for mortality, NLR and LDH levels on admission might be useful prognostic tools.https://doi.org/10.1186/s12877-022-03059-7Prognostic factorsGeriatric patientsCovid-19Neutrophile-to-lymphocyte ratio, lactate dehydrogenase |
| spellingShingle | Uğur Önal Muhammet Gülhan Neşe Demirci Ahmet Özden Nazlı Erol Sema Işık Sedat Gülten Fatma Atalay Nilay Çöplü Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19 BMC Geriatrics Prognostic factors Geriatric patients Covid-19 Neutrophile-to-lymphocyte ratio, lactate dehydrogenase |
| title | Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19 |
| title_full | Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19 |
| title_fullStr | Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19 |
| title_full_unstemmed | Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19 |
| title_short | Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19 |
| title_sort | prognostic value of neutrophile to lymphocyte ratio nlr and lactate dehydrogenase ldh levels for geriatric patients with covid 19 |
| topic | Prognostic factors Geriatric patients Covid-19 Neutrophile-to-lymphocyte ratio, lactate dehydrogenase |
| url | https://doi.org/10.1186/s12877-022-03059-7 |
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