Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models
The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies. Thus, relevant preclinical models are needed to investigate thyroid cancer biology and novel treatments. Different preclinical mo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2022-12-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2022-1636.pdf |
| _version_ | 1797962275094528000 |
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| author | Min Ji Jeon Bryan R. Haugen |
| author_facet | Min Ji Jeon Bryan R. Haugen |
| author_sort | Min Ji Jeon |
| collection | DOAJ |
| description | The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies. Thus, relevant preclinical models are needed to investigate thyroid cancer biology and novel treatments. Different preclinical models have recently emerged with advances in thyroid cancer genetics, mouse modeling and new cell lines. Choosing the appropriate model according to the research question is crucial to studying thyroid cancer. This review will discuss the current preclinical models frequently used in thyroid cancer research, from cell lines to mouse models, and future perspectives on patient-derived and humanized preclinical models in this field. |
| first_indexed | 2024-04-11T01:10:49Z |
| format | Article |
| id | doaj.art-734dbe8cbe75451b98f531fecf8ceb4c |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-11T01:10:49Z |
| publishDate | 2022-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-734dbe8cbe75451b98f531fecf8ceb4c2023-01-04T05:41:52ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782022-12-0137683083810.3803/EnM.2022.16362355Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse ModelsMin Ji Jeon0Bryan R. Haugen1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USAThe overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies. Thus, relevant preclinical models are needed to investigate thyroid cancer biology and novel treatments. Different preclinical models have recently emerged with advances in thyroid cancer genetics, mouse modeling and new cell lines. Choosing the appropriate model according to the research question is crucial to studying thyroid cancer. This review will discuss the current preclinical models frequently used in thyroid cancer research, from cell lines to mouse models, and future perspectives on patient-derived and humanized preclinical models in this field.http://www.e-enm.org/upload/pdf/enm-2022-1636.pdfthyroid neoplasmcell linemodels, animalanimals, genetically modified |
| spellingShingle | Min Ji Jeon Bryan R. Haugen Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models Endocrinology and Metabolism thyroid neoplasm cell line models, animal animals, genetically modified |
| title | Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models |
| title_full | Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models |
| title_fullStr | Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models |
| title_full_unstemmed | Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models |
| title_short | Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models |
| title_sort | preclinical models of follicular cell derived thyroid cancer an overview from cancer cell lines to mouse models |
| topic | thyroid neoplasm cell line models, animal animals, genetically modified |
| url | http://www.e-enm.org/upload/pdf/enm-2022-1636.pdf |
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