Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan
Noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA (cfDNA) present in the spent blastocyst medium (SBM) of human blastocysts has emerged as an alternative for classical preimplantation genetic testing for aneuploidy (PGT-A). The major benefit is to avoid possibl...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2023-03-01
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| Series: | Fertility & Reproduction |
| Subjects: | |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661318223720015 |
| _version_ | 1797237002394927104 |
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| author | Chun-Kai Chen Wei-Han Huang Tiencheng Arthur Chang Kuang-Han Chao Wang-Fung Chiang Hsin-Yi Yeh Szu-Yu Shen |
| author_facet | Chun-Kai Chen Wei-Han Huang Tiencheng Arthur Chang Kuang-Han Chao Wang-Fung Chiang Hsin-Yi Yeh Szu-Yu Shen |
| author_sort | Chun-Kai Chen |
| collection | DOAJ |
| description | Noninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA (cfDNA) present in the spent blastocyst medium (SBM) of human blastocysts has emerged as an alternative for classical preimplantation genetic testing for aneuploidy (PGT-A). The major benefit is to avoid possible damage to the trophectoderm and subsequently increase the implantation potential of the embryo. niPGT-A provides more information including the ploidy state of both trophectoderm and inner cell mass compared to invasive PGT-A in which only a few trophectoderm cells are assessed. This study was to report our first successful experience solely using niPGT-A to select embryos to transfer resulting in a successful delivery. This practical application is believed to be the first case report in Taiwan and can serve as an innovative model for other clinics to apply niPGT-A. |
| first_indexed | 2024-04-24T17:12:49Z |
| format | Article |
| id | doaj.art-734dc5ea29074aebb1f6de12d796cfd5 |
| institution | Directory Open Access Journal |
| issn | 2661-3182 2661-3174 |
| language | English |
| last_indexed | 2024-04-24T17:12:49Z |
| publishDate | 2023-03-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Fertility & Reproduction |
| spelling | doaj.art-734dc5ea29074aebb1f6de12d796cfd52024-03-28T08:43:40ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742023-03-010501737710.1142/S2661318223720015Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in TaiwanChun-Kai Chen0Wei-Han Huang1Tiencheng Arthur Chang2Kuang-Han Chao3Wang-Fung Chiang4Hsin-Yi Yeh5Szu-Yu Shen6Hope Fertility and PGT Center, Taipei, TaiwanHope Fertility and PGT Center, Taipei, TaiwanDepartment of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, Texas, USADepartment of Obstetrics and Gynecology, College of Medicine and Hospital, National Taiwan University, Taipei, TaiwanHope Fertility and PGT Center, Taipei, TaiwanHope Fertility and PGT Center, Taipei, TaiwanHope Fertility and PGT Center, Taipei, TaiwanNoninvasive preimplantation genetic testing for aneuploidy (niPGT-A) using cell-free DNA (cfDNA) present in the spent blastocyst medium (SBM) of human blastocysts has emerged as an alternative for classical preimplantation genetic testing for aneuploidy (PGT-A). The major benefit is to avoid possible damage to the trophectoderm and subsequently increase the implantation potential of the embryo. niPGT-A provides more information including the ploidy state of both trophectoderm and inner cell mass compared to invasive PGT-A in which only a few trophectoderm cells are assessed. This study was to report our first successful experience solely using niPGT-A to select embryos to transfer resulting in a successful delivery. This practical application is believed to be the first case report in Taiwan and can serve as an innovative model for other clinics to apply niPGT-A.https://www.worldscientific.com/doi/10.1142/S2661318223720015Noninvasive Preimplantation Genetic Testing for Aneuploidy (niPGT-A)Preimplantation Genetic Testing for Aneuploidy (PGT-A)Spent Blastocyst Medium (SBM) |
| spellingShingle | Chun-Kai Chen Wei-Han Huang Tiencheng Arthur Chang Kuang-Han Chao Wang-Fung Chiang Hsin-Yi Yeh Szu-Yu Shen Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan Fertility & Reproduction Noninvasive Preimplantation Genetic Testing for Aneuploidy (niPGT-A) Preimplantation Genetic Testing for Aneuploidy (PGT-A) Spent Blastocyst Medium (SBM) |
| title | Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan |
| title_full | Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan |
| title_fullStr | Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan |
| title_full_unstemmed | Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan |
| title_short | Implementation of Noninvasive Preimplantation Genetic Testing for Aneuploidy with Spent Blastocyst Medium into Clinical and Laboratory Practice: The First Successful Experience in Taiwan |
| title_sort | implementation of noninvasive preimplantation genetic testing for aneuploidy with spent blastocyst medium into clinical and laboratory practice the first successful experience in taiwan |
| topic | Noninvasive Preimplantation Genetic Testing for Aneuploidy (niPGT-A) Preimplantation Genetic Testing for Aneuploidy (PGT-A) Spent Blastocyst Medium (SBM) |
| url | https://www.worldscientific.com/doi/10.1142/S2661318223720015 |
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