The role of mitochondria in redox signaling of muscle homeostasis
In the past, contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle. As research advances, clear evidence has revealed a more complete role of ROS under both physiologic and pathologic conditions. Central to the role of ROS is the r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Journal of Sport and Health Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095254620300089 |
| _version_ | 1818605806700986368 |
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| author | Li Li Ji Dongwook Yeo Chounghun Kang Tianou Zhang |
| author_facet | Li Li Ji Dongwook Yeo Chounghun Kang Tianou Zhang |
| author_sort | Li Li Ji |
| collection | DOAJ |
| description | In the past, contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle. As research advances, clear evidence has revealed a more complete role of ROS under both physiologic and pathologic conditions. Central to the role of ROS is the redox signaling pathways that control exercise-induced major physiologic and cellular responses and adaptations, such as mitochondrial biogenesis, mitophagy, mitochondrial morphologic dynamics, antioxidant defense, and inflammation. The current review focuses on how muscle contraction and immobilization may activate or inhibit redox signalings and their impact on muscle mitochondrial homeostasis and physiologic implications. |
| first_indexed | 2024-12-16T14:00:49Z |
| format | Article |
| id | doaj.art-734e0f65b16043ac98a7b62c6e33ccbe |
| institution | Directory Open Access Journal |
| issn | 2095-2546 |
| language | English |
| last_indexed | 2024-12-16T14:00:49Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Sport and Health Science |
| spelling | doaj.art-734e0f65b16043ac98a7b62c6e33ccbe2022-12-21T22:29:05ZengElsevierJournal of Sport and Health Science2095-25462020-09-0195386393The role of mitochondria in redox signaling of muscle homeostasisLi Li Ji0Dongwook Yeo1Chounghun Kang2Tianou Zhang3The Laboratory of Physiological Hygiene and Exercise Science, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA; Corresponding author.Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USADepartment of Physical Education, Inha University, Incheon 22212, Republic of KoreaDepartment of Kinesiology, Health and Nutrition, University of Texas at San Antonio, San Antonio, TX 78249, USAIn the past, contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle. As research advances, clear evidence has revealed a more complete role of ROS under both physiologic and pathologic conditions. Central to the role of ROS is the redox signaling pathways that control exercise-induced major physiologic and cellular responses and adaptations, such as mitochondrial biogenesis, mitophagy, mitochondrial morphologic dynamics, antioxidant defense, and inflammation. The current review focuses on how muscle contraction and immobilization may activate or inhibit redox signalings and their impact on muscle mitochondrial homeostasis and physiologic implications.http://www.sciencedirect.com/science/article/pii/S2095254620300089AntioxidantExercisePeroxisome-proliferator-activated receptor γ coactivator 1-αReactive oxygen speciesRedox signalingSkeletal muscle |
| spellingShingle | Li Li Ji Dongwook Yeo Chounghun Kang Tianou Zhang The role of mitochondria in redox signaling of muscle homeostasis Journal of Sport and Health Science Antioxidant Exercise Peroxisome-proliferator-activated receptor γ coactivator 1-α Reactive oxygen species Redox signaling Skeletal muscle |
| title | The role of mitochondria in redox signaling of muscle homeostasis |
| title_full | The role of mitochondria in redox signaling of muscle homeostasis |
| title_fullStr | The role of mitochondria in redox signaling of muscle homeostasis |
| title_full_unstemmed | The role of mitochondria in redox signaling of muscle homeostasis |
| title_short | The role of mitochondria in redox signaling of muscle homeostasis |
| title_sort | role of mitochondria in redox signaling of muscle homeostasis |
| topic | Antioxidant Exercise Peroxisome-proliferator-activated receptor γ coactivator 1-α Reactive oxygen species Redox signaling Skeletal muscle |
| url | http://www.sciencedirect.com/science/article/pii/S2095254620300089 |
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