Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort
Abstract Background Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is limited information about the development of patient-reported health-re...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12890-020-1147-5 |
| _version_ | 1818880721452793856 |
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| author | Johanna I. Lutter Rudolf A. Jörres Kathrin Kahnert Larissa Schwarzkopf Michael Studnicka Stefan Karrasch Holger Schulz Claus F. Vogelmeier Rolf Holle for the COSYCONET Study Group |
| author_facet | Johanna I. Lutter Rudolf A. Jörres Kathrin Kahnert Larissa Schwarzkopf Michael Studnicka Stefan Karrasch Holger Schulz Claus F. Vogelmeier Rolf Holle for the COSYCONET Study Group |
| author_sort | Johanna I. Lutter |
| collection | DOAJ |
| description | Abstract Background Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is limited information about the development of patient-reported health-related quality of life (HRQL) over the full range of the natural history of COPD. We examined the longitudinal association between change in FEV1 and change in disease-specific and generic HRQL. Methods We analysed data of 1734 patients with COPD participating in the COSYCONET cohort with up to 3 years of follow-up. Patients completed the Saint George’s Respiratory Questionnaire (SGRQ) and the EQ-5D Visual Analog Scale (EQ VAS). Change score models were used to investigate the relationship between HRQL and FEV1 and to calculate mean changes in HRQL per FEV1 change categories [decrease (≤ − 100 ml), no change, increase (≥ 100 ml)] after 3 years. Applying hierarchical linear models (HLM), we estimated the cross-sectional between-subject difference and the longitudinal within-subject change of HRQL as related to a FEV1 difference or change. Results We observed a statistically significant deterioration in SGRQ (total score + 1.3 units) after 3 years, which was completely driven by the activity component (+ 4 units). No significant change was found for the generic EQ VAS. Over the same period, 58% of patients experienced a decrease in FEV1, 28% were recorded as no change in FEV1, and 13% experienced an increase. The relationship between HRQL and FEV1 was found to be approximately linear with decrease in FEV1 being statistically significantly associated with a deterioration in SGRQ (+ 3.20 units). Increase in FEV1 was associated with improvements in SGRQ (− 3.81 units). The associations between change in FEV1 and the EQ VAS were similar. Results of the HLMs were consistent and highly statistically significant, indicating cross-sectional and longitudinal associations. The largest estimates were found for the association between FEV1 and the SGRQ activity domain. Conclusions Difference and change in FEV1 over time correlate with difference and change in disease-specific and generic HRQL. We conclude, that deterioration of HRQL should induce timely re-examination of physical status and lung function and possibly reassessment of therapeutic regimes. Trial registration NCT01245933 . Date of registration: 18 November 2010. |
| first_indexed | 2024-12-19T14:50:28Z |
| format | Article |
| id | doaj.art-734ec5e86d20490bbdfa027cb0b73df9 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-19T14:50:28Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-734ec5e86d20490bbdfa027cb0b73df92022-12-21T20:16:50ZengBMCBMC Pulmonary Medicine1471-24662020-05-0120111210.1186/s12890-020-1147-5Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohortJohanna I. Lutter0Rudolf A. Jörres1Kathrin Kahnert2Larissa Schwarzkopf3Michael Studnicka4Stefan Karrasch5Holger Schulz6Claus F. Vogelmeier7Rolf Holle8for the COSYCONET Study GroupInstitute of Health Economics and Health Care Management, Helmholtz Zentrum München, GmbH – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)Department of Internal Medicine V, University of Munich (LMU), Comprehensive Pneumology Center, Member of the German Center for Lung ResearchInstitute of Health Economics and Health Care Management, Helmholtz Zentrum München, GmbH – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)Department of Pneumology, Paracelsus Medical University Salzburg, Universitätsklinikum SalzburgInstitute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)Institute of Epidemiology, Helmholtz Zentrum München (GmbH) – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL)Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, GmbH – German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)Abstract Background Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is limited information about the development of patient-reported health-related quality of life (HRQL) over the full range of the natural history of COPD. We examined the longitudinal association between change in FEV1 and change in disease-specific and generic HRQL. Methods We analysed data of 1734 patients with COPD participating in the COSYCONET cohort with up to 3 years of follow-up. Patients completed the Saint George’s Respiratory Questionnaire (SGRQ) and the EQ-5D Visual Analog Scale (EQ VAS). Change score models were used to investigate the relationship between HRQL and FEV1 and to calculate mean changes in HRQL per FEV1 change categories [decrease (≤ − 100 ml), no change, increase (≥ 100 ml)] after 3 years. Applying hierarchical linear models (HLM), we estimated the cross-sectional between-subject difference and the longitudinal within-subject change of HRQL as related to a FEV1 difference or change. Results We observed a statistically significant deterioration in SGRQ (total score + 1.3 units) after 3 years, which was completely driven by the activity component (+ 4 units). No significant change was found for the generic EQ VAS. Over the same period, 58% of patients experienced a decrease in FEV1, 28% were recorded as no change in FEV1, and 13% experienced an increase. The relationship between HRQL and FEV1 was found to be approximately linear with decrease in FEV1 being statistically significantly associated with a deterioration in SGRQ (+ 3.20 units). Increase in FEV1 was associated with improvements in SGRQ (− 3.81 units). The associations between change in FEV1 and the EQ VAS were similar. Results of the HLMs were consistent and highly statistically significant, indicating cross-sectional and longitudinal associations. The largest estimates were found for the association between FEV1 and the SGRQ activity domain. Conclusions Difference and change in FEV1 over time correlate with difference and change in disease-specific and generic HRQL. We conclude, that deterioration of HRQL should induce timely re-examination of physical status and lung function and possibly reassessment of therapeutic regimes. Trial registration NCT01245933 . Date of registration: 18 November 2010.http://link.springer.com/article/10.1186/s12890-020-1147-5COPDCohortLongitudinalPatient reported outcomeHealth statusPhysical activity |
| spellingShingle | Johanna I. Lutter Rudolf A. Jörres Kathrin Kahnert Larissa Schwarzkopf Michael Studnicka Stefan Karrasch Holger Schulz Claus F. Vogelmeier Rolf Holle for the COSYCONET Study Group Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort BMC Pulmonary Medicine COPD Cohort Longitudinal Patient reported outcome Health status Physical activity |
| title | Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort |
| title_full | Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort |
| title_fullStr | Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort |
| title_full_unstemmed | Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort |
| title_short | Health-related quality of life associates with change in FEV1 in COPD: results from the COSYCONET cohort |
| title_sort | health related quality of life associates with change in fev1 in copd results from the cosyconet cohort |
| topic | COPD Cohort Longitudinal Patient reported outcome Health status Physical activity |
| url | http://link.springer.com/article/10.1186/s12890-020-1147-5 |
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