Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study
BackgroundCarotid atherosclerosis, especially the rupture of unstable plaques, plays an important role in the development of stroke. A novel lipid ratio, the non-high-density lipoprotein cholesterol (non-HDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, contains both atherogenic and anti-at...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.875134/full |
| _version_ | 1818049975187144704 |
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| author | Anran Wang Yapeng Li Lue Zhou Kai Liu Shaohua Li Ce Zong Bo Song Yuan Gao Yusheng Li Chuansheng Tian Yurong Xing Yuming Xu Longde Wang Longde Wang |
| author_facet | Anran Wang Yapeng Li Lue Zhou Kai Liu Shaohua Li Ce Zong Bo Song Yuan Gao Yusheng Li Chuansheng Tian Yurong Xing Yuming Xu Longde Wang Longde Wang |
| author_sort | Anran Wang |
| collection | DOAJ |
| description | BackgroundCarotid atherosclerosis, especially the rupture of unstable plaques, plays an important role in the development of stroke. A novel lipid ratio, the non-high-density lipoprotein cholesterol (non-HDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, contains both atherogenic and anti-atherogenic particle information, and has been shown to be associated with carotid atherosclerosis. However, there is no data on evaluating the association between non-HDL-C/HDL-C ratio and carotid plaque stability.MethodsThis study was carried out on 27,436 urban workers aged 20 years or older who participated in a comprehensive health screening between January 2016 and December 2017. Carotid plaque stability was assessed using ultrasonography. Multinomial logistic regression models were used to explore the relationship between the non-HDL-C/HDL-C ratio and carotid plaque stability by odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses were performed to verify the robustness of the results.ResultsCarotid plaque was detected in 7,161 (26.1%) participants, with stable and unstable plaque accounting for 3,277 (11.9%) and 3,884 (14.2%), respectively. The prevalence of stable carotid plaque substantially increased with increasing non-HDL-C/HDL-C ratio quartile levels (p for trend < 0.001) and with a similar association for unstable carotid plaque (p for trend < 0.001). The mean non-HDL-C/HDL-C ratios (mean ± SD) of non-carotid plaque (2.9 ± 1.1), stable carotid plaque (3.2 ± 1.2), and unstable carotid plaque (3.4 ± 1.4) gradually increased (p < 0.001). In multinomial logistic regression, ORs (95% CIs) for the highest vs. lowest quartile of the non-HDL-C/HDL-C ratio were 1.70 (1.48–1.95) between stable carotid plaques and no carotid plaque, 2.34 (2.06–2.67) between unstable carotid plaques and no carotid plaque, and 1.38 (1.18–1.61) between unstable carotid plaques and stable carotid plaque, after adjusting for common cardiovascular risk factors. The results of subgroup analysis and sensitivity analysis were similar.ConclusionOur findings suggested that the non-HDL-C/HDL-C ratio was significantly associated with carotid plaque stability and might be a useful indicator for the early identification of high-risk carotid plaque. |
| first_indexed | 2024-12-10T10:46:07Z |
| format | Article |
| id | doaj.art-73507eca6af84618a52645e5683d549a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T10:46:07Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-73507eca6af84618a52645e5683d549a2022-12-22T01:52:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.875134875134Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional studyAnran Wang0Yapeng Li1Lue Zhou2Kai Liu3Shaohua Li4Ce Zong5Bo Song6Yuan Gao7Yusheng Li8Chuansheng Tian9Yurong Xing10Yuming Xu11Longde Wang12Longde Wang13Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaChinese Preventive Medicine Association, Beijing, ChinaPhysical Examination Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaThe General Office of Stroke Prevention Project Committee, National Health Commission of the People's Republic of China, Beijing, ChinaBackgroundCarotid atherosclerosis, especially the rupture of unstable plaques, plays an important role in the development of stroke. A novel lipid ratio, the non-high-density lipoprotein cholesterol (non-HDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, contains both atherogenic and anti-atherogenic particle information, and has been shown to be associated with carotid atherosclerosis. However, there is no data on evaluating the association between non-HDL-C/HDL-C ratio and carotid plaque stability.MethodsThis study was carried out on 27,436 urban workers aged 20 years or older who participated in a comprehensive health screening between January 2016 and December 2017. Carotid plaque stability was assessed using ultrasonography. Multinomial logistic regression models were used to explore the relationship between the non-HDL-C/HDL-C ratio and carotid plaque stability by odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses were performed to verify the robustness of the results.ResultsCarotid plaque was detected in 7,161 (26.1%) participants, with stable and unstable plaque accounting for 3,277 (11.9%) and 3,884 (14.2%), respectively. The prevalence of stable carotid plaque substantially increased with increasing non-HDL-C/HDL-C ratio quartile levels (p for trend < 0.001) and with a similar association for unstable carotid plaque (p for trend < 0.001). The mean non-HDL-C/HDL-C ratios (mean ± SD) of non-carotid plaque (2.9 ± 1.1), stable carotid plaque (3.2 ± 1.2), and unstable carotid plaque (3.4 ± 1.4) gradually increased (p < 0.001). In multinomial logistic regression, ORs (95% CIs) for the highest vs. lowest quartile of the non-HDL-C/HDL-C ratio were 1.70 (1.48–1.95) between stable carotid plaques and no carotid plaque, 2.34 (2.06–2.67) between unstable carotid plaques and no carotid plaque, and 1.38 (1.18–1.61) between unstable carotid plaques and stable carotid plaque, after adjusting for common cardiovascular risk factors. The results of subgroup analysis and sensitivity analysis were similar.ConclusionOur findings suggested that the non-HDL-C/HDL-C ratio was significantly associated with carotid plaque stability and might be a useful indicator for the early identification of high-risk carotid plaque.https://www.frontiersin.org/articles/10.3389/fneur.2022.875134/fulllipid rationon-HDL-C/HDL-Ccarotid plaquestabilitycross-sectional study |
| spellingShingle | Anran Wang Yapeng Li Lue Zhou Kai Liu Shaohua Li Ce Zong Bo Song Yuan Gao Yusheng Li Chuansheng Tian Yurong Xing Yuming Xu Longde Wang Longde Wang Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study Frontiers in Neurology lipid ratio non-HDL-C/HDL-C carotid plaque stability cross-sectional study |
| title | Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study |
| title_full | Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study |
| title_fullStr | Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study |
| title_full_unstemmed | Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study |
| title_short | Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study |
| title_sort | non hdl c hdl c ratio is associated with carotid plaque stability in general population a cross sectional study |
| topic | lipid ratio non-HDL-C/HDL-C carotid plaque stability cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.875134/full |
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