Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation
Alzheimer’s disease (AD) is a devastating neurodegenerative disease with limited therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and restore neuronal cell function has previously been explored in AD animal models, yet most of these transplantation methods have ut...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-05-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897231164712 |
| _version_ | 1797821634184216576 |
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| author | Phoebe Strell Sether T. Johnson Chris Carchi Walter C. Low |
| author_facet | Phoebe Strell Sether T. Johnson Chris Carchi Walter C. Low |
| author_sort | Phoebe Strell |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a devastating neurodegenerative disease with limited therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and restore neuronal cell function has previously been explored in AD animal models, yet most of these transplantation methods have utilized primary cell cultures or donor grafts. Blastocyst complementation offers a novel approach to generate a renewable exogenic source of neurons. These exogenic neurons derived from stem cells would develop with the in vivo context of the inductive cues within a host, thus recapitulating the neuron-specific characteristics and physiology. AD affects many different cell types including hippocampal neurons and limbic projection neurons, cholinergic nucleus basis and medial septal neurons, noradrenergic locus coeruleus neurons, serotonergic raphe neurons, and limbic and cortical interneurons. Blastocyst complementation can be adapted to generate these specific neuronal cells afflicted by AD pathology, by ablating important cell type and brain region–specific developmental genes. This review discusses the current state of neuronal transplantation to replace specific neural cell types affected by AD, and the developmental biology to identify candidate genes for knockout in embryos for creating niches to generate exogenic neurons via blastocyst complementation. |
| first_indexed | 2024-03-13T09:56:40Z |
| format | Article |
| id | doaj.art-7350eea284034b4b8e378cd6e33527ad |
| institution | Directory Open Access Journal |
| issn | 1555-3892 |
| language | English |
| last_indexed | 2024-03-13T09:56:40Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-7350eea284034b4b8e378cd6e33527ad2023-05-23T20:33:19ZengSAGE PublishingCell Transplantation1555-38922023-05-013210.1177/09636897231164712Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for ImplantationPhoebe Strell0Sether T. Johnson1Chris Carchi2Walter C. Low3Stem Cell Institute, University of Minnesota, Minneapolis, MN, USADepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USADepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USADepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USAAlzheimer’s disease (AD) is a devastating neurodegenerative disease with limited therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and restore neuronal cell function has previously been explored in AD animal models, yet most of these transplantation methods have utilized primary cell cultures or donor grafts. Blastocyst complementation offers a novel approach to generate a renewable exogenic source of neurons. These exogenic neurons derived from stem cells would develop with the in vivo context of the inductive cues within a host, thus recapitulating the neuron-specific characteristics and physiology. AD affects many different cell types including hippocampal neurons and limbic projection neurons, cholinergic nucleus basis and medial septal neurons, noradrenergic locus coeruleus neurons, serotonergic raphe neurons, and limbic and cortical interneurons. Blastocyst complementation can be adapted to generate these specific neuronal cells afflicted by AD pathology, by ablating important cell type and brain region–specific developmental genes. This review discusses the current state of neuronal transplantation to replace specific neural cell types affected by AD, and the developmental biology to identify candidate genes for knockout in embryos for creating niches to generate exogenic neurons via blastocyst complementation.https://doi.org/10.1177/09636897231164712 |
| spellingShingle | Phoebe Strell Sether T. Johnson Chris Carchi Walter C. Low Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation Cell Transplantation |
| title | Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation |
| title_full | Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation |
| title_fullStr | Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation |
| title_full_unstemmed | Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation |
| title_short | Neuronal Transplantation for Alzheimer’s Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation |
| title_sort | neuronal transplantation for alzheimer s disease and prospects for generating exogenic neurons as a source of cells for implantation |
| url | https://doi.org/10.1177/09636897231164712 |
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