Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
Background: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunction. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315822200184X |
| _version_ | 1818476013763428352 |
|---|---|
| author | Paola Fuentes-Claramonte Núria Ramiro Llanos Torres Isabel Argila-Plaza Pilar Salgado-Pineda Joan Soler-Vidal María Ángeles García-León Auria Albacete Clara Bosque Francesco Panicalli Ester Boix Josep Munuera Josep Tristany Salvador Sarró Miquel Bernardo Raymond Salvador Peter J. McKenna Edith Pomarol-Clotet |
| author_facet | Paola Fuentes-Claramonte Núria Ramiro Llanos Torres Isabel Argila-Plaza Pilar Salgado-Pineda Joan Soler-Vidal María Ángeles García-León Auria Albacete Clara Bosque Francesco Panicalli Ester Boix Josep Munuera Josep Tristany Salvador Sarró Miquel Bernardo Raymond Salvador Peter J. McKenna Edith Pomarol-Clotet |
| author_sort | Paola Fuentes-Claramonte |
| collection | DOAJ |
| description | Background: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunction. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as lack of volition. Method: Twenty-four DSM-5 schizophrenic patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS) and 30 healthy controls underwent fMRI during performance of the Computerized Multiple Elements Test (CMET), a task designed to measure poor organization of goal directed behaviour or ‘goal neglect’. Negative symptoms were rated using the PANSS and the Clinical Assessment Interview for Negative Symptoms (CAINS). Results: On whole brain analysis, the ANS patients showed no significant clusters of reduced activation compared to the healthy controls. In contrast, the HNS patients showed hypoactivation compared to the healthy controls in the left anterior frontal cortex, the right dorsolateral prefrontal cortex (DLPFC), the anterior insula bilaterally and the bilateral inferior parietal cortex. When compared to the ANS patients, the HNS patients showed reduced activation in the left anterior frontal cortex, the left DLPFC and the left inferior parietal cortex. After controlling for disorganization scores, differences remained in clusters in the left anterior frontal cortex and the bilateral inferior parietal cortex. Conclusions: This study provides evidence that reduced prefrontal activation, perhaps especially in the left anterior frontal cortex, is a brain functional correlate of negative symptoms in schizophrenia. The simultaneous finding of reduced inferior parietal cortex activation was unexpected, but could reflect this region’s involvement in cognitive control, particularly the ‘regulative’ component of this. |
| first_indexed | 2024-12-10T09:20:16Z |
| format | Article |
| id | doaj.art-7353d9a00ef64ac2a4bd00e46263b5a4 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-10T09:20:16Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-7353d9a00ef64ac2a4bd00e46263b5a42022-12-22T01:54:43ZengElsevierNeuroImage: Clinical2213-15822022-01-0135103119Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglectPaola Fuentes-Claramonte0Núria Ramiro1Llanos Torres2Isabel Argila-Plaza3Pilar Salgado-Pineda4Joan Soler-Vidal5María Ángeles García-León6Auria Albacete7Clara Bosque8Francesco Panicalli9Ester Boix10Josep Munuera11Josep Tristany12Salvador Sarró13Miquel Bernardo14Raymond Salvador15Peter J. McKenna16Edith Pomarol-Clotet17FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, SpainPsychiatry department, Hospital Sant Rafael, Barcelona, SpainHospital Mare de Dèu de la Mercé, Unitat Polivalent, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain; Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, SpainBenito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, SpainBenito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, SpainMental Health Department, Hospital de Mataró, Mataró, SpainDiagnostic Imaging Department, Hospital Sant Joan de Déu, Barcelona, SpainHospital Sagrat Cor, Martorell, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, SpainCIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain; Barcelona Clínic Schizophrenia Unit, Hospital Clínic of Barcelona, Institute of Neuroscience, Barcelona, Spain; Universitat de Barcelona, Barcelona, Spain; Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain; Corresponding author at: FIDMAG, Germanes Hospitalàries, Benito Menni CASM, C/. Dr. Antoni Pujadas 38, 08830 Sant Boi de Llobregat, Barcelona, Spain.FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, SpainBackground: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunction. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as lack of volition. Method: Twenty-four DSM-5 schizophrenic patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS) and 30 healthy controls underwent fMRI during performance of the Computerized Multiple Elements Test (CMET), a task designed to measure poor organization of goal directed behaviour or ‘goal neglect’. Negative symptoms were rated using the PANSS and the Clinical Assessment Interview for Negative Symptoms (CAINS). Results: On whole brain analysis, the ANS patients showed no significant clusters of reduced activation compared to the healthy controls. In contrast, the HNS patients showed hypoactivation compared to the healthy controls in the left anterior frontal cortex, the right dorsolateral prefrontal cortex (DLPFC), the anterior insula bilaterally and the bilateral inferior parietal cortex. When compared to the ANS patients, the HNS patients showed reduced activation in the left anterior frontal cortex, the left DLPFC and the left inferior parietal cortex. After controlling for disorganization scores, differences remained in clusters in the left anterior frontal cortex and the bilateral inferior parietal cortex. Conclusions: This study provides evidence that reduced prefrontal activation, perhaps especially in the left anterior frontal cortex, is a brain functional correlate of negative symptoms in schizophrenia. The simultaneous finding of reduced inferior parietal cortex activation was unexpected, but could reflect this region’s involvement in cognitive control, particularly the ‘regulative’ component of this.http://www.sciencedirect.com/science/article/pii/S221315822200184XSchizophreniaNegative symptomsFrontal lobesExecutive functionfMRI |
| spellingShingle | Paola Fuentes-Claramonte Núria Ramiro Llanos Torres Isabel Argila-Plaza Pilar Salgado-Pineda Joan Soler-Vidal María Ángeles García-León Auria Albacete Clara Bosque Francesco Panicalli Ester Boix Josep Munuera Josep Tristany Salvador Sarró Miquel Bernardo Raymond Salvador Peter J. McKenna Edith Pomarol-Clotet Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect NeuroImage: Clinical Schizophrenia Negative symptoms Frontal lobes Executive function fMRI |
| title | Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect |
| title_full | Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect |
| title_fullStr | Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect |
| title_full_unstemmed | Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect |
| title_short | Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect |
| title_sort | negative schizophrenic symptoms as prefrontal cortex dysfunction examination using a task measuring goal neglect |
| topic | Schizophrenia Negative symptoms Frontal lobes Executive function fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S221315822200184X |
| work_keys_str_mv | AT paolafuentesclaramonte negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT nuriaramiro negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT llanostorres negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT isabelargilaplaza negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT pilarsalgadopineda negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT joansolervidal negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT mariaangelesgarcialeon negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT auriaalbacete negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT clarabosque negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT francescopanicalli negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT esterboix negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT josepmunuera negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT joseptristany negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT salvadorsarro negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT miquelbernardo negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT raymondsalvador negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT peterjmckenna negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect AT edithpomarolclotet negativeschizophrenicsymptomsasprefrontalcortexdysfunctionexaminationusingataskmeasuringgoalneglect |