Circulating levels of Bcl-2 and its expression in the nasal mucosa of patients with chronic rhinosinusitis
<b>Aim: </b>To evaluate expression of anti-apoptotic Bcl-2 protein in the nasal tissue and its levels in blood serum of patients with chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP).<br /> <b>Material and methods:</b> Expression of Bcl-2 in the si...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Scientific Medical Center
2022-12-01
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| Series: | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| Subjects: | |
| Online Access: | https://www.clinmedkaz.org/download/circulating-levels-of-bcl-2-and-its-expression-in-the-nasal-mucosa-of-patients-with-chronic-12689.pdf |
| Summary: | <b>Aim: </b>To evaluate expression of anti-apoptotic Bcl-2 protein in the nasal tissue and its levels in blood serum of patients with chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP).<br />
<b>Material and methods:</b> Expression of Bcl-2 in the sinonasal tissue and its levels in blood serum of patients with CRSsNP and CRSwNP were evaluated immunohistochemically and using ELISA, respectively.<br />
<b>Results:</b> In patients with CRSsNP, Bcl-2 was overexpressed in nasal epithelial cells mainly in the atrophic regions. However, its upregulation was also observed in regions with epithelial cell proliferation. Immunostaining for Bcl-2 was stronger both in the stroma and epithelial lining compared with control subjects. The level of Bcl-2 in blood serum was elevated in both forms of chronic rhinosinusitis with a more pronounced increase in CRSwNP.<br />
<b>Conclusion:</b> CRSsNP and especially CRSwNP are associated with overexpression of anti-apoptotic Bcl-2 in nasal epithelial cells and in the lamina propria against the background of elevated circulating concentrations of Bcl-2. |
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| ISSN: | 1812-2892 2313-1519 |