Cognitive and renal dysfunction in the elderly
ABSTRACT Cognitive impairment has been associated with several diseases and organic disturbances but few studies have explored the relationship between renal function and cognition. Objective: The aim of this study was to compare the renal function of elderly patients with and without Alzheimer...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Neurologia Cognitiva e do Comportamento
|
| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000400397&lng=en&tlng=en |
| _version_ | 1828931405326843904 |
|---|---|
| author | Francisco Souza do Carmo Sueli Luciano Pires Milton Luiz Gorzoni Luiz Antonio Miorin |
| author_facet | Francisco Souza do Carmo Sueli Luciano Pires Milton Luiz Gorzoni Luiz Antonio Miorin |
| author_sort | Francisco Souza do Carmo |
| collection | DOAJ |
| description | ABSTRACT Cognitive impairment has been associated with several diseases and organic disturbances but few studies have explored the relationship between renal function and cognition. Objective: The aim of this study was to compare the renal function of elderly patients with and without Alzheimer's disease, and to identify potential associated comorbidities, as well as the presence of microalbuminuria. Methods: A group of 60 patients with dementia syndrome and probable Alzheimer's disease, and 20 patients without dementias, followed at the Geriatric outpatient unit of the Santa Casa de São Paulo Hospital, were selected for this study. Results: The results showed that the groups studied differed in terms of age, gender and Mini-Mental State Exam score, but no statistical difference was found for the presence of comorbidities (diabetes mellitus, dyslipidemia and systemic arterial hypertension). A significant difference in estimated creatinine clearance was observed between the two groups, with the Alzheimer's disease patients presenting significantly lower values than control subjects. Similarly, analysis of a portion of the two groups for the presence of microalbuminuria revealed a statistically significant difference between the two groups. Conclusion: The study conclusions were that patients with Alzheimer's disease had lower glomerular filtration and a higher incidence of microalbuminuria, yet without having more classic risk factors for Alzheimer's disease such as systemic arterial hypertension, diabetes mellitus or dyslipidemia. |
| first_indexed | 2024-12-14T00:46:37Z |
| format | Article |
| id | doaj.art-735564f753054c31a8bc1813793ba0ac |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-12-14T00:46:37Z |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-735564f753054c31a8bc1813793ba0ac2022-12-21T23:24:05ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57647439740210.1590/S1980-57642013DN74000007S1980-57642013000400397Cognitive and renal dysfunction in the elderlyFrancisco Souza do CarmoSueli Luciano PiresMilton Luiz GorzoniLuiz Antonio MiorinABSTRACT Cognitive impairment has been associated with several diseases and organic disturbances but few studies have explored the relationship between renal function and cognition. Objective: The aim of this study was to compare the renal function of elderly patients with and without Alzheimer's disease, and to identify potential associated comorbidities, as well as the presence of microalbuminuria. Methods: A group of 60 patients with dementia syndrome and probable Alzheimer's disease, and 20 patients without dementias, followed at the Geriatric outpatient unit of the Santa Casa de São Paulo Hospital, were selected for this study. Results: The results showed that the groups studied differed in terms of age, gender and Mini-Mental State Exam score, but no statistical difference was found for the presence of comorbidities (diabetes mellitus, dyslipidemia and systemic arterial hypertension). A significant difference in estimated creatinine clearance was observed between the two groups, with the Alzheimer's disease patients presenting significantly lower values than control subjects. Similarly, analysis of a portion of the two groups for the presence of microalbuminuria revealed a statistically significant difference between the two groups. Conclusion: The study conclusions were that patients with Alzheimer's disease had lower glomerular filtration and a higher incidence of microalbuminuria, yet without having more classic risk factors for Alzheimer's disease such as systemic arterial hypertension, diabetes mellitus or dyslipidemia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000400397&lng=en&tlng=enelderlyAlzheimer's diseasedementiarenal functionalbuminuria. |
| spellingShingle | Francisco Souza do Carmo Sueli Luciano Pires Milton Luiz Gorzoni Luiz Antonio Miorin Cognitive and renal dysfunction in the elderly Dementia & Neuropsychologia elderly Alzheimer's disease dementia renal function albuminuria. |
| title | Cognitive and renal dysfunction in the elderly |
| title_full | Cognitive and renal dysfunction in the elderly |
| title_fullStr | Cognitive and renal dysfunction in the elderly |
| title_full_unstemmed | Cognitive and renal dysfunction in the elderly |
| title_short | Cognitive and renal dysfunction in the elderly |
| title_sort | cognitive and renal dysfunction in the elderly |
| topic | elderly Alzheimer's disease dementia renal function albuminuria. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000400397&lng=en&tlng=en |
| work_keys_str_mv | AT franciscosouzadocarmo cognitiveandrenaldysfunctionintheelderly AT suelilucianopires cognitiveandrenaldysfunctionintheelderly AT miltonluizgorzoni cognitiveandrenaldysfunctionintheelderly AT luizantoniomiorin cognitiveandrenaldysfunctionintheelderly |