Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness

Novel cellular systems unveil mucosal melanoma initiating cells and a role for PI3K/Akt/mTOR pathway in mucosal melanoma fitness

Abstract Background Mucosal Melanomas (MM) are highly aggressive neoplasms arising from mucosal melanocytes. Current treatments offer a limited survival benefit for patients with advanced MM; moreover, the lack of pre-clinical cellular systems has significantly limited the understanding of their imm...

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Bibliographic Details
Main Authors: Matilde Monti, Luisa Benerini Gatta, Mattia Bugatti, Irene Pezzali, Sara Picinoli, Marcello Manfredi, Antonio Lavazza, Virginia Vita Vanella, Veronica De Giorgis, Lucia Zanatta, Francesco Missale, Silvia Lonardi, Benedetta Zanetti, Giovanni Bozzoni, Moris Cadei, Andrea Abate, Barbara Vergani, Piera Balzarini, Simonetta Battocchio, Carla Facco, Mario Turri-Zanoni, Paolo Castelnuovo, Piero Nicolai, Ester Fonsatti, Biagio Eugenio Leone, Emilio Marengo, Sandra Sigala, Roberto Ronca, Michela Perego, Davide Lombardi, William Vermi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
Mucosal melanomas
Cell lines
Melanoma stem cells
MITF
PI3K/AKT/mTOR
Online Access:https://doi.org/10.1186/s12967-023-04784-2

Internet

https://doi.org/10.1186/s12967-023-04784-2

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