Statistical mechanics of cell decision-making: the cell migration force distribution
Cell decision-making is the cellular process of responding to microenvironmental cues. This can be regarded as the regulation of cell’s intrinsic variables to extrinsic stimuli. Currently, little is known about the principles dictating cell decision-making. Regarding cells as Bayesian decision-maker...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2018-06-01
|
| Series: | Journal of the Mechanical Behavior of Materials |
| Online Access: | https://doi.org/10.1515/jmbm-2018-0001 |
| _version_ | 1818717138658000896 |
|---|---|
| author | Hatzikirou Haralampos |
| author_facet | Hatzikirou Haralampos |
| author_sort | Hatzikirou Haralampos |
| collection | DOAJ |
| description | Cell decision-making is the cellular process of responding to microenvironmental cues. This can be regarded as the regulation of cell’s intrinsic variables to extrinsic stimuli. Currently, little is known about the principles dictating cell decision-making. Regarding cells as Bayesian decision-makers under energetic constraints, I postulate the principle of least microenvironmental uncertainty principle (LEUP). This is translated into a free-energy principle and I develop a statistical mechanics theory for cell decision-making. I exhibit the potential of LEUP in the case of cell migration. In particular, I calculate the dependence of cell locomotion force on the steady state distribution of adhesion receptors. Finally, the associated migration velocity allows for the reproduction of the cell anomalous diffusion, as observed in cell culture experiments. |
| first_indexed | 2024-12-17T19:30:23Z |
| format | Article |
| id | doaj.art-735dc21226f94d6885cde5028c158092 |
| institution | Directory Open Access Journal |
| issn | 0334-8938 2191-0243 |
| language | English |
| last_indexed | 2024-12-17T19:30:23Z |
| publishDate | 2018-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Journal of the Mechanical Behavior of Materials |
| spelling | doaj.art-735dc21226f94d6885cde5028c1580922022-12-21T21:35:16ZengDe GruyterJournal of the Mechanical Behavior of Materials0334-89382191-02432018-06-01271-2638010.1515/jmbm-2018-0001Statistical mechanics of cell decision-making: the cell migration force distributionHatzikirou Haralampos0Braunschweig Integrated Centre of Systems Biology and Helmholtz Center for Infection Research, Inhoffenstr 7, 38124 Braunschweig, GermanyCell decision-making is the cellular process of responding to microenvironmental cues. This can be regarded as the regulation of cell’s intrinsic variables to extrinsic stimuli. Currently, little is known about the principles dictating cell decision-making. Regarding cells as Bayesian decision-makers under energetic constraints, I postulate the principle of least microenvironmental uncertainty principle (LEUP). This is translated into a free-energy principle and I develop a statistical mechanics theory for cell decision-making. I exhibit the potential of LEUP in the case of cell migration. In particular, I calculate the dependence of cell locomotion force on the steady state distribution of adhesion receptors. Finally, the associated migration velocity allows for the reproduction of the cell anomalous diffusion, as observed in cell culture experiments.https://doi.org/10.1515/jmbm-2018-0001 |
| spellingShingle | Hatzikirou Haralampos Statistical mechanics of cell decision-making: the cell migration force distribution Journal of the Mechanical Behavior of Materials |
| title | Statistical mechanics of cell decision-making: the cell migration force distribution |
| title_full | Statistical mechanics of cell decision-making: the cell migration force distribution |
| title_fullStr | Statistical mechanics of cell decision-making: the cell migration force distribution |
| title_full_unstemmed | Statistical mechanics of cell decision-making: the cell migration force distribution |
| title_short | Statistical mechanics of cell decision-making: the cell migration force distribution |
| title_sort | statistical mechanics of cell decision making the cell migration force distribution |
| url | https://doi.org/10.1515/jmbm-2018-0001 |
| work_keys_str_mv | AT hatzikirouharalampos statisticalmechanicsofcelldecisionmakingthecellmigrationforcedistribution |