Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy?
Background: Polyhydramnios is a common cause of adverse pregnancy outcomes. The prediction of polyhydramnios in early pregnancy may lead to improved treatments and will diminish these adverse outcomes. Objective: This study aims to investigate the role of biochemical markers in antenatal screening t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2021-10-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805172 |
| _version_ | 1811247761297768448 |
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| author | Ozgur Sahin H. Egemen Tolunay Tufan Arslanca S. Banu Arslanca |
| author_facet | Ozgur Sahin H. Egemen Tolunay Tufan Arslanca S. Banu Arslanca |
| author_sort | Ozgur Sahin |
| collection | DOAJ |
| description | Background: Polyhydramnios is a common cause of adverse pregnancy outcomes. The prediction of polyhydramnios in early pregnancy may lead to improved treatments and will diminish these adverse outcomes. Objective: This study aims to investigate the role of biochemical markers in antenatal screening tests to predict idiopathic polyhydramnios. Methods: Patient records were retrospectively evaluated in this case-control group study. Pregnant women (160 in total) were included in the study (this included 47 pregnant women diagnosed with idiopathic polyhydramnios and 113 healthy pregnant women as a control group). Results: Alpha-fetoprotein, unconjugated estriol, and total beta-human chorionic gonadotropin values were similar in both groups (p = 0.296, p = 0.573, p = 0.284). There was no significant difference between the group diagnosed with idiopathic polyhydramnios and the control group when the first-trimester screening test parameter, pregnancy-associated plasma protein-A, was examined (p = 0.102). Conclusion: Biochemical markers examined in prenatal screening tests in the first and second trimesters were insufficient to predict idiopathic Polyhydramnios. The reasons for this are that our study was retrospective, and the patient population was low. We believe that a prospective study with a larger population of patients should be conducted for more meaningful results. |
| first_indexed | 2024-04-12T15:15:21Z |
| format | Article |
| id | doaj.art-735dee3d1e844b0d95dbac2f27ff0e6f |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-12T15:15:21Z |
| publishDate | 2021-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-735dee3d1e844b0d95dbac2f27ff0e6f2022-12-22T03:27:38ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-10-014851071107410.31083/j.ceog4805172S0390-6663(21)00011-7Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy?Ozgur Sahin0H. Egemen Tolunay1Tufan Arslanca2S. Banu Arslanca3Department of Obstetrics and Gynecology, Canakkale State Hospital, 17010 Canakkale, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, 06070 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Ufuk University, 06510 Ankara, TurkeyDepartment of Obstetrics and Gynecology, Etlik Zübeyde Hanım Maternity and Women’s Health Teaching and Research Hospital, 06070 Ankara, TurkeyBackground: Polyhydramnios is a common cause of adverse pregnancy outcomes. The prediction of polyhydramnios in early pregnancy may lead to improved treatments and will diminish these adverse outcomes. Objective: This study aims to investigate the role of biochemical markers in antenatal screening tests to predict idiopathic polyhydramnios. Methods: Patient records were retrospectively evaluated in this case-control group study. Pregnant women (160 in total) were included in the study (this included 47 pregnant women diagnosed with idiopathic polyhydramnios and 113 healthy pregnant women as a control group). Results: Alpha-fetoprotein, unconjugated estriol, and total beta-human chorionic gonadotropin values were similar in both groups (p = 0.296, p = 0.573, p = 0.284). There was no significant difference between the group diagnosed with idiopathic polyhydramnios and the control group when the first-trimester screening test parameter, pregnancy-associated plasma protein-A, was examined (p = 0.102). Conclusion: Biochemical markers examined in prenatal screening tests in the first and second trimesters were insufficient to predict idiopathic Polyhydramnios. The reasons for this are that our study was retrospective, and the patient population was low. We believe that a prospective study with a larger population of patients should be conducted for more meaningful results.https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805172antenatal screeningbiochemical markerspolyhydramnios |
| spellingShingle | Ozgur Sahin H. Egemen Tolunay Tufan Arslanca S. Banu Arslanca Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy? Clinical and Experimental Obstetrics & Gynecology antenatal screening biochemical markers polyhydramnios |
| title | Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy? |
| title_full | Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy? |
| title_fullStr | Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy? |
| title_full_unstemmed | Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy? |
| title_short | Can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy? |
| title_sort | can serum biochemical markers be used to establish a relationship between idiopathic polyhydramnios and antenatal aneuploidy |
| topic | antenatal screening biochemical markers polyhydramnios |
| url | https://www.imrpress.com/journal/CEOG/48/5/10.31083/j.ceog4805172 |
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