Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections

Exploiting phage-antibiotic synergies to disrupt Pseudomonas aeruginosa PAO1 biofilms in the context of orthopedic infections

ABSTRACT In recent years, bacteriophages (or phages) have reentered the spotlight as alternative or adjuvant therapeutic agents to antibiotics. Their efficacy in more recalcitrant forms of infections like biofilms, frequently encountered in the orthopedic setting, remains less characterized. The pre...

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Bibliographic Details
Main Authors: Steven De Soir, Hortence Parée, Nur Hidayatul Nazirah Kamarudin, Jeroen Wagemans, Rob Lavigne, Annabel Braem, Maya Merabishvili, Daniel De Vos, Jean-Paul Pirnay, Françoise Van Bambeke
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:Microbiology Spectrum
Subjects:
bacteriophage therapy
antibiotics
Pseudomonas aeruginosa
biofilms
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03219-23

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