Genomic Instability in Circulating Tumor Cells
Circulating tumor cells (CTCs) can promote distant metastases and can be obtained through minimally invasive liquid biopsy for clinical assessment in cancer patients. Having both genomic heterogeneity and instability as common features, the genetic characterization of CTCs can serve as a powerful to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/3001 |
| _version_ | 1797550799228764160 |
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| author | Monique Oliveira Freitas John Gartner Aline Rangel-Pozzo Sabine Mai |
| author_facet | Monique Oliveira Freitas John Gartner Aline Rangel-Pozzo Sabine Mai |
| author_sort | Monique Oliveira Freitas |
| collection | DOAJ |
| description | Circulating tumor cells (CTCs) can promote distant metastases and can be obtained through minimally invasive liquid biopsy for clinical assessment in cancer patients. Having both genomic heterogeneity and instability as common features, the genetic characterization of CTCs can serve as a powerful tool for a better understanding of the molecular changes occurring at tumor initiation and during tumor progression/metastasis. In this review, we will highlight recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability in CTCs. We will focus on the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine. |
| first_indexed | 2024-03-10T15:34:34Z |
| format | Article |
| id | doaj.art-7365d492e2bd4ee48553401612d500b1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:34:34Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7365d492e2bd4ee48553401612d500b12023-11-20T17:20:08ZengMDPI AGCancers2072-66942020-10-011210300110.3390/cancers12103001Genomic Instability in Circulating Tumor CellsMonique Oliveira Freitas0John Gartner1Aline Rangel-Pozzo2Sabine Mai3Cell Biology, Research Institute of Oncology and Hematology, University of Manitoba, Cancer Care Manitoba, Winnipeg, MB R3C 2B7, CanadaDepartments of Pathology and Immunology, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P5, CanadaCell Biology, Research Institute of Oncology and Hematology, University of Manitoba, Cancer Care Manitoba, Winnipeg, MB R3C 2B7, CanadaCell Biology, Research Institute of Oncology and Hematology, University of Manitoba, Cancer Care Manitoba, Winnipeg, MB R3C 2B7, CanadaCirculating tumor cells (CTCs) can promote distant metastases and can be obtained through minimally invasive liquid biopsy for clinical assessment in cancer patients. Having both genomic heterogeneity and instability as common features, the genetic characterization of CTCs can serve as a powerful tool for a better understanding of the molecular changes occurring at tumor initiation and during tumor progression/metastasis. In this review, we will highlight recent advances in the detection and quantification of tumor cell heterogeneity and genomic instability in CTCs. We will focus on the contribution of chromosome instability studies to genetic heterogeneity in CTCs at the single-CTC level by discussing data from different cancer subtypes and their impact on diagnosis and precision medicine.https://www.mdpi.com/2072-6694/12/10/3001circulating tumor cells (CTCs)chromosome instabilitytumor heterogeneity |
| spellingShingle | Monique Oliveira Freitas John Gartner Aline Rangel-Pozzo Sabine Mai Genomic Instability in Circulating Tumor Cells Cancers circulating tumor cells (CTCs) chromosome instability tumor heterogeneity |
| title | Genomic Instability in Circulating Tumor Cells |
| title_full | Genomic Instability in Circulating Tumor Cells |
| title_fullStr | Genomic Instability in Circulating Tumor Cells |
| title_full_unstemmed | Genomic Instability in Circulating Tumor Cells |
| title_short | Genomic Instability in Circulating Tumor Cells |
| title_sort | genomic instability in circulating tumor cells |
| topic | circulating tumor cells (CTCs) chromosome instability tumor heterogeneity |
| url | https://www.mdpi.com/2072-6694/12/10/3001 |
| work_keys_str_mv | AT moniqueoliveirafreitas genomicinstabilityincirculatingtumorcells AT johngartner genomicinstabilityincirculatingtumorcells AT alinerangelpozzo genomicinstabilityincirculatingtumorcells AT sabinemai genomicinstabilityincirculatingtumorcells |