TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4<sup>+</sup> T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation o...

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Bibliographic Details
Main Authors:	Mellanby Richard J, Cambrook Helen, Turner Darryl G, O’Connor Richard A, Leech Melanie D, Kurschus Florian C, MacDonald Andrew S, Arnold Bernd, Anderton Stephen M
Format:	Article
Language:	English
Published:	BMC 2012-10-01
Series:	Journal of Neuroinflammation
Subjects:	Multiple sclerosis Experimental autoimmune encephalomyelitis Dendritic cells Myelin basic protein
Online Access:	http://www.jneuroinflammation.com/content/9/1/248

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