Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand.
AKI is one of the most serious complications of leptospirosis, an important zoonosis in the tropics. Recently, NGAL, one of the novel AKI biomarkers, is extensively studied in various specific settings such as sepsis, cardiac surgery, and radiocontrast nephropathy. In this multicenter study, we aime...
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Public Library of Science (PLoS)
2015-01-01
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| Online Access: | http://europepmc.org/articles/PMC4667882?pdf=render |
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| author | Nattachai Srisawat Kearkiat Praditpornsilpa Kanitha Patarakul Malee Techapornrung Tinnapop Daraswang Theerapon Sukmark Kamol Khositrangsikun Apinya Fakthongyoo Petchdee Oranrigsupak Laksamon Praderm Ummarit Suwattanasilpa Sadudee Peerapornratana Passisd Loahaveeravat Nattachai Suwachittanont Thaksa-on Wirotwan Chayanat Phonork Sarinya Kumpunya Khajohn Tiranathanagul Chintana Chirathaworn Somchai Eiam-ong Kriang Tungsanga Visith Sitprija John A Kellum Natavudh Townamchai Thai Lepto-AKI study group |
| author_facet | Nattachai Srisawat Kearkiat Praditpornsilpa Kanitha Patarakul Malee Techapornrung Tinnapop Daraswang Theerapon Sukmark Kamol Khositrangsikun Apinya Fakthongyoo Petchdee Oranrigsupak Laksamon Praderm Ummarit Suwattanasilpa Sadudee Peerapornratana Passisd Loahaveeravat Nattachai Suwachittanont Thaksa-on Wirotwan Chayanat Phonork Sarinya Kumpunya Khajohn Tiranathanagul Chintana Chirathaworn Somchai Eiam-ong Kriang Tungsanga Visith Sitprija John A Kellum Natavudh Townamchai Thai Lepto-AKI study group |
| author_sort | Nattachai Srisawat |
| collection | DOAJ |
| description | AKI is one of the most serious complications of leptospirosis, an important zoonosis in the tropics. Recently, NGAL, one of the novel AKI biomarkers, is extensively studied in various specific settings such as sepsis, cardiac surgery, and radiocontrast nephropathy. In this multicenter study, we aimed to study the role of NGAL as an early marker and an outcome predictor of leptospirosis associated AKI. Patients who presented with clinical suspiciousness of leptospirosis were prospectively enrolled in 9 centers from August 2012 to November 2014. The first day of enrollment was the first day of clinical suspicious leptospirosis. Blood and urine samples were serially collected on the first three days and day 7 after enrollment. We used three standard techniques (microscopic agglutination test, direct culture, and PCR technique) to confirm the diagnosis of leptospirosis. KDIGO criteria were used for AKI diagnosis. Recovery was defined as alive and not requiring dialysis during hospitalization or maintaining maximum KDIGO stage at hospital discharge. Of the 221 recruited cases, 113 cases were leptospirosis confirmed cases. Thirty seven percent developed AKI. Median uNGAL and pNGAL levels in those developing AKI were significantly higher than in patients not developing AKI [253.8 (631.4) vs 24.1 (49.6) ng/ml, p < 0.001] and [1,030 (802.5) vs 192.0 (209.0) ng/ml, p < 0.001], respectively. uNGAL and pNGAL levels associated with AKI had AUC-ROC of 0.91, and 0.92, respectively. Both of urine NGAL and pNGAL level between AKI-recovery group and AKI-non recovery were comparable. From this multicenter study, uNGAL and pNGAL provided the promising result to be a marker for leptospirosis associated AKI. However, both of them did not show the potential role to be the predictor of renal recovery in this specific setting. |
| first_indexed | 2024-04-12T08:52:52Z |
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| id | doaj.art-7365ff51ff9b46e6b69a3a837a95be5a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T08:52:52Z |
| publishDate | 2015-01-01 |
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| spelling | doaj.art-7365ff51ff9b46e6b69a3a837a95be5a2022-12-22T03:39:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014336710.1371/journal.pone.0143367Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand.Nattachai SrisawatKearkiat PraditpornsilpaKanitha PatarakulMalee TechapornrungTinnapop DaraswangTheerapon SukmarkKamol KhositrangsikunApinya FakthongyooPetchdee OranrigsupakLaksamon PradermUmmarit SuwattanasilpaSadudee PeerapornratanaPassisd LoahaveeravatNattachai SuwachittanontThaksa-on WirotwanChayanat PhonorkSarinya KumpunyaKhajohn TiranathanagulChintana ChirathawornSomchai Eiam-ongKriang TungsangaVisith SitprijaJohn A KellumNatavudh TownamchaiThai Lepto-AKI study groupAKI is one of the most serious complications of leptospirosis, an important zoonosis in the tropics. Recently, NGAL, one of the novel AKI biomarkers, is extensively studied in various specific settings such as sepsis, cardiac surgery, and radiocontrast nephropathy. In this multicenter study, we aimed to study the role of NGAL as an early marker and an outcome predictor of leptospirosis associated AKI. Patients who presented with clinical suspiciousness of leptospirosis were prospectively enrolled in 9 centers from August 2012 to November 2014. The first day of enrollment was the first day of clinical suspicious leptospirosis. Blood and urine samples were serially collected on the first three days and day 7 after enrollment. We used three standard techniques (microscopic agglutination test, direct culture, and PCR technique) to confirm the diagnosis of leptospirosis. KDIGO criteria were used for AKI diagnosis. Recovery was defined as alive and not requiring dialysis during hospitalization or maintaining maximum KDIGO stage at hospital discharge. Of the 221 recruited cases, 113 cases were leptospirosis confirmed cases. Thirty seven percent developed AKI. Median uNGAL and pNGAL levels in those developing AKI were significantly higher than in patients not developing AKI [253.8 (631.4) vs 24.1 (49.6) ng/ml, p < 0.001] and [1,030 (802.5) vs 192.0 (209.0) ng/ml, p < 0.001], respectively. uNGAL and pNGAL levels associated with AKI had AUC-ROC of 0.91, and 0.92, respectively. Both of urine NGAL and pNGAL level between AKI-recovery group and AKI-non recovery were comparable. From this multicenter study, uNGAL and pNGAL provided the promising result to be a marker for leptospirosis associated AKI. However, both of them did not show the potential role to be the predictor of renal recovery in this specific setting.http://europepmc.org/articles/PMC4667882?pdf=render |
| spellingShingle | Nattachai Srisawat Kearkiat Praditpornsilpa Kanitha Patarakul Malee Techapornrung Tinnapop Daraswang Theerapon Sukmark Kamol Khositrangsikun Apinya Fakthongyoo Petchdee Oranrigsupak Laksamon Praderm Ummarit Suwattanasilpa Sadudee Peerapornratana Passisd Loahaveeravat Nattachai Suwachittanont Thaksa-on Wirotwan Chayanat Phonork Sarinya Kumpunya Khajohn Tiranathanagul Chintana Chirathaworn Somchai Eiam-ong Kriang Tungsanga Visith Sitprija John A Kellum Natavudh Townamchai Thai Lepto-AKI study group Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. PLoS ONE |
| title | Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. |
| title_full | Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. |
| title_fullStr | Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. |
| title_full_unstemmed | Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. |
| title_short | Neutrophil Gelatinase Associated Lipocalin (NGAL) in Leptospirosis Acute Kidney Injury: A Multicenter Study in Thailand. |
| title_sort | neutrophil gelatinase associated lipocalin ngal in leptospirosis acute kidney injury a multicenter study in thailand |
| url | http://europepmc.org/articles/PMC4667882?pdf=render |
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