Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness

Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness

Summary: Metastasis is the leading cause of high ovarian-cancer-related mortality worldwide. Three major processes constitute the whole metastatic cascade: invasion, intravasation, and extravasation. Tumor cells often reprogram their metabolism to gain advantages in proliferation and survival. Howev...

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Bibliographic Details
Main Authors: Shengmiao Chen, Yiran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shuyuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B. Qi, Xue-Song Liu, Tiffany Horng, Haopeng Wang, Dan Ye, Zhengjiang Zhu, Suwen Zhao, Gaofeng Fan
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012585

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