N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review
Rheumatoid arthritis (RA), one of the most common autoimmune diseases, is characterized by immune cell infiltration, fibroblast-like synovial cell hyperproliferation, and cartilage and bone destruction. To date, numerous studies have demonstrated that immune cells are one of the key targets for the...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.731842/full |
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| author | Sha Wu Xiao-Feng Li Xiao-Feng Li Yuan-Yuan Wu Su-Qin Yin Cheng Huang Jun Li |
| author_facet | Sha Wu Xiao-Feng Li Xiao-Feng Li Yuan-Yuan Wu Su-Qin Yin Cheng Huang Jun Li |
| author_sort | Sha Wu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA), one of the most common autoimmune diseases, is characterized by immune cell infiltration, fibroblast-like synovial cell hyperproliferation, and cartilage and bone destruction. To date, numerous studies have demonstrated that immune cells are one of the key targets for the treatment of RA. N6-methyladenosine (m6A) is the most common internal modification to eukaryotic mRNA, which is involved in the splicing, stability, export, and degradation of RNA metabolism. m6A methylated-related genes are divided into writers, erasers, and readers, and they are critical for the regulation of cell life. They play a significant role in various biological processes, such as virus replication and cell differentiation by controlling gene expression. Furthermore, a growing number of studies have indicated that m6A is associated with the occurrence of numerous diseases, such as lung cancer, bladder cancer, gastric cancer, acute myeloid leukemia, and hepatocellular carcinoma. In this review, we summarize the history of m6A research and recent progress on RA research concerning m6A enzymes. The relationship between m6A enzymes, immune cells, and RA suggests that m6A modification offers evidence for the pathogenesis of RA, which will help in the development of new therapies for RA. |
| first_indexed | 2024-12-21T22:46:05Z |
| format | Article |
| id | doaj.art-73675f980a9a4d95afcf78a28f02b695 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T22:46:05Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-73675f980a9a4d95afcf78a28f02b6952022-12-21T18:47:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-09-011210.3389/fimmu.2021.731842731842N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive ReviewSha Wu0Xiao-Feng Li1Xiao-Feng Li2Yuan-Yuan Wu3Su-Qin Yin4Cheng Huang5Jun Li6Anhui Institute of Innovative Drugs, The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, ChinaAnhui Institute of Innovative Drugs, The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, ChinaPostdoctoral Station of Clinical Medicine of Anhui Medical University, Hefei, ChinaAnhui Institute of Innovative Drugs, The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, ChinaAnhui Institute of Innovative Drugs, The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, ChinaAnhui Institute of Innovative Drugs, The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, ChinaAnhui Institute of Innovative Drugs, The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, ChinaRheumatoid arthritis (RA), one of the most common autoimmune diseases, is characterized by immune cell infiltration, fibroblast-like synovial cell hyperproliferation, and cartilage and bone destruction. To date, numerous studies have demonstrated that immune cells are one of the key targets for the treatment of RA. N6-methyladenosine (m6A) is the most common internal modification to eukaryotic mRNA, which is involved in the splicing, stability, export, and degradation of RNA metabolism. m6A methylated-related genes are divided into writers, erasers, and readers, and they are critical for the regulation of cell life. They play a significant role in various biological processes, such as virus replication and cell differentiation by controlling gene expression. Furthermore, a growing number of studies have indicated that m6A is associated with the occurrence of numerous diseases, such as lung cancer, bladder cancer, gastric cancer, acute myeloid leukemia, and hepatocellular carcinoma. In this review, we summarize the history of m6A research and recent progress on RA research concerning m6A enzymes. The relationship between m6A enzymes, immune cells, and RA suggests that m6A modification offers evidence for the pathogenesis of RA, which will help in the development of new therapies for RA.https://www.frontiersin.org/articles/10.3389/fimmu.2021.731842/fullN6-methyladenosinerheumatoid arthritisimmune cellsautoimmune diseasecancers |
| spellingShingle | Sha Wu Xiao-Feng Li Xiao-Feng Li Yuan-Yuan Wu Su-Qin Yin Cheng Huang Jun Li N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review Frontiers in Immunology N6-methyladenosine rheumatoid arthritis immune cells autoimmune disease cancers |
| title | N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review |
| title_full | N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review |
| title_fullStr | N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review |
| title_full_unstemmed | N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review |
| title_short | N6-Methyladenosine and Rheumatoid Arthritis: A Comprehensive Review |
| title_sort | n6 methyladenosine and rheumatoid arthritis a comprehensive review |
| topic | N6-methyladenosine rheumatoid arthritis immune cells autoimmune disease cancers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.731842/full |
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