Combination vaccines
The combination of diphtheria, tetanus, and pertussis vaccines into a single product has been central to the protection of the pediatric population over the past 50 years. The addition of inactivated polio, Haemophilus influenzae, and hepatitis B vaccines into the combination has facilitated the int...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Global Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.jgid.org/article.asp?issn=0974-777X;year=2011;volume=3;issue=1;spage=63;epage=72;aulast=Skibinski |
| _version_ | 1818546967586799616 |
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| author | David AG Skibinski Barbara C Baudner Manmohan Singh Derek T O′Hagan |
| author_facet | David AG Skibinski Barbara C Baudner Manmohan Singh Derek T O′Hagan |
| author_sort | David AG Skibinski |
| collection | DOAJ |
| description | The combination of diphtheria, tetanus, and pertussis vaccines into a single product has been central to the protection of the pediatric population over the past 50 years. The addition of inactivated polio, Haemophilus influenzae, and hepatitis B vaccines into the combination has facilitated the introduction of these vaccines into recommended immunization schedules by reducing the number of injections required and has therefore increased immunization compliance. However, the development of these combinations encountered numerous challenges, including the reduced response to Haemophilus influenzae vaccine when given in combination; the need to consolidate the differences in the immunization schedule (hepatitis B); and the need to improve the safety profile of the diphtheria, tetanus, and pertussis combination. Here, we review these challenges and also discuss future prospects for combination vaccines. |
| first_indexed | 2024-12-12T08:00:19Z |
| format | Article |
| id | doaj.art-7367edd88a2b4ac99b5e7b6a7edcb001 |
| institution | Directory Open Access Journal |
| issn | 0974-777X |
| language | English |
| last_indexed | 2024-12-12T08:00:19Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Global Infectious Diseases |
| spelling | doaj.art-7367edd88a2b4ac99b5e7b6a7edcb0012022-12-22T00:32:09ZengWolters Kluwer Medknow PublicationsJournal of Global Infectious Diseases0974-777X2011-01-0131637210.4103/0974-777X.77298Combination vaccinesDavid AG SkibinskiBarbara C BaudnerManmohan SinghDerek T O′HaganThe combination of diphtheria, tetanus, and pertussis vaccines into a single product has been central to the protection of the pediatric population over the past 50 years. The addition of inactivated polio, Haemophilus influenzae, and hepatitis B vaccines into the combination has facilitated the introduction of these vaccines into recommended immunization schedules by reducing the number of injections required and has therefore increased immunization compliance. However, the development of these combinations encountered numerous challenges, including the reduced response to Haemophilus influenzae vaccine when given in combination; the need to consolidate the differences in the immunization schedule (hepatitis B); and the need to improve the safety profile of the diphtheria, tetanus, and pertussis combination. Here, we review these challenges and also discuss future prospects for combination vaccines.http://www.jgid.org/article.asp?issn=0974-777X;year=2011;volume=3;issue=1;spage=63;epage=72;aulast=SkibinskiAdjuvantCombination vaccineDiphtheriaHaemophilus influenzaHepatitis BNeisseria meningitidisPertussisPoliovirusStreptococcus pneumoniae Tetanus |
| spellingShingle | David AG Skibinski Barbara C Baudner Manmohan Singh Derek T O′Hagan Combination vaccines Journal of Global Infectious Diseases Adjuvant Combination vaccine Diphtheria Haemophilus influenza Hepatitis B Neisseria meningitidis Pertussis Poliovirus Streptococcus pneumoniae Tetanus |
| title | Combination vaccines |
| title_full | Combination vaccines |
| title_fullStr | Combination vaccines |
| title_full_unstemmed | Combination vaccines |
| title_short | Combination vaccines |
| title_sort | combination vaccines |
| topic | Adjuvant Combination vaccine Diphtheria Haemophilus influenza Hepatitis B Neisseria meningitidis Pertussis Poliovirus Streptococcus pneumoniae Tetanus |
| url | http://www.jgid.org/article.asp?issn=0974-777X;year=2011;volume=3;issue=1;spage=63;epage=72;aulast=Skibinski |
| work_keys_str_mv | AT davidagskibinski combinationvaccines AT barbaracbaudner combinationvaccines AT manmohansingh combinationvaccines AT derektohagan combinationvaccines |