Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons
Aim: to investigate the effect of the vaccine "Grippol" on radioresistance with respect to proton irradiation. Material and methods. The effect of the vaccine "Grippol" the survival of the animals was studied in mice CBAxC57BI F1, which was immunized for 10 days prior to proton i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Saratov State Medical University
2015-12-01
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| Series: | Саратовский научно-медицинский журнал |
| Subjects: | |
| Online Access: | http://www.ssmj.ru/system/files/2015_04-01_656-658.pdf |
| _version_ | 1818652908514705408 |
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| author | Ivanov А.А. Abrosimova A.N. Bulinina Т.М. |
| author_facet | Ivanov А.А. Abrosimova A.N. Bulinina Т.М. |
| author_sort | Ivanov А.А. |
| collection | DOAJ |
| description | Aim: to investigate the effect of the vaccine "Grippol" on radioresistance with respect to proton irradiation. Material and methods. The effect of the vaccine "Grippol" the survival of the animals was studied in mice CBAxC57BI F1, which was immunized for 10 days prior to proton irradiation. Results. It is shown that proton irradiation causes the death of the animals at all doses tested: 9% at a dose of 7.0 Gy; 10% — 8.0 Gy and 33% after irradiation at a dose of 8.5 Gy, at the same time the survival rate after pre vaccination study groups was 100%. It seems appropriate to further study the impact of the vaccine "Grippol" at low doses of proton irradiation using appropriate test evaluation of hematological, im-munological, genetic, physiological and other factors. Conclusion. The vaccine "Grippol" introduction into mice before lethal proton irradiation increases survival of protected animals. |
| first_indexed | 2024-12-17T02:29:29Z |
| format | Article |
| id | doaj.art-736d1856097c4b879178317606631298 |
| institution | Directory Open Access Journal |
| issn | 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-17T02:29:29Z |
| publishDate | 2015-12-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-736d1856097c4b8791783176066312982022-12-21T22:07:00ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал2076-25182015-12-011146566584253Effects of the vaccine "Grippol" on resistance of mice after irradiation by protonsIvanov А.А.0Abrosimova A.N.1Bulinina Т.М.2State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyAim: to investigate the effect of the vaccine "Grippol" on radioresistance with respect to proton irradiation. Material and methods. The effect of the vaccine "Grippol" the survival of the animals was studied in mice CBAxC57BI F1, which was immunized for 10 days prior to proton irradiation. Results. It is shown that proton irradiation causes the death of the animals at all doses tested: 9% at a dose of 7.0 Gy; 10% — 8.0 Gy and 33% after irradiation at a dose of 8.5 Gy, at the same time the survival rate after pre vaccination study groups was 100%. It seems appropriate to further study the impact of the vaccine "Grippol" at low doses of proton irradiation using appropriate test evaluation of hematological, im-munological, genetic, physiological and other factors. Conclusion. The vaccine "Grippol" introduction into mice before lethal proton irradiation increases survival of protected animals.http://www.ssmj.ru/system/files/2015_04-01_656-658.pdfGrippolmiceprotonsradioresistancesurvivalvaccination |
| spellingShingle | Ivanov А.А. Abrosimova A.N. Bulinina Т.М. Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons Саратовский научно-медицинский журнал Grippol mice protons radioresistance survival vaccination |
| title | Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons |
| title_full | Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons |
| title_fullStr | Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons |
| title_full_unstemmed | Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons |
| title_short | Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons |
| title_sort | effects of the vaccine grippol on resistance of mice after irradiation by protons |
| topic | Grippol mice protons radioresistance survival vaccination |
| url | http://www.ssmj.ru/system/files/2015_04-01_656-658.pdf |
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