FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli
FtsN promotes the inward synthesis of septal peptidoglycan (sPG) through the FtsWI complex during bacterial cell division. Here, Lyu et al. apply single-molecule microscopy on E. coli to show that FtsN proteins (I) move processively at a speed similar to that of FtsWI molecules. (II) can be divided...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33404-8 |
| _version_ | 1811201020582166528 |
|---|---|
| author | Zhixin Lyu Atsushi Yahashiri Xinxing Yang Joshua W. McCausland Gabriela M. Kaus Ryan McQuillen David S. Weiss Jie Xiao |
| author_facet | Zhixin Lyu Atsushi Yahashiri Xinxing Yang Joshua W. McCausland Gabriela M. Kaus Ryan McQuillen David S. Weiss Jie Xiao |
| author_sort | Zhixin Lyu |
| collection | DOAJ |
| description | FtsN promotes the inward synthesis of septal peptidoglycan (sPG) through the FtsWI complex during bacterial cell division. Here, Lyu et al. apply single-molecule microscopy on E. coli to show that FtsN proteins (I) move processively at a speed similar to that of FtsWI molecules. (II) can be divided into two populations based on their speeds, and (III) their movement is driven exclusively by peptidoglycan synthesis |
| first_indexed | 2024-04-12T02:14:35Z |
| format | Article |
| id | doaj.art-736e43fa29c241ae825e8f762cdebbd2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T02:14:35Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-736e43fa29c241ae825e8f762cdebbd22022-12-22T03:52:18ZengNature PortfolioNature Communications2041-17232022-09-0113111610.1038/s41467-022-33404-8FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coliZhixin Lyu0Atsushi Yahashiri1Xinxing Yang2Joshua W. McCausland3Gabriela M. Kaus4Ryan McQuillen5David S. Weiss6Jie Xiao7Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of MedicineDepartment of Microbiology and Immunology, University of Iowa Carver College of MedicineDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of MedicineDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of MedicineDepartment of Microbiology and Immunology, University of Iowa Carver College of MedicineDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of MedicineDepartment of Microbiology and Immunology, University of Iowa Carver College of MedicineDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins School of MedicineFtsN promotes the inward synthesis of septal peptidoglycan (sPG) through the FtsWI complex during bacterial cell division. Here, Lyu et al. apply single-molecule microscopy on E. coli to show that FtsN proteins (I) move processively at a speed similar to that of FtsWI molecules. (II) can be divided into two populations based on their speeds, and (III) their movement is driven exclusively by peptidoglycan synthesishttps://doi.org/10.1038/s41467-022-33404-8 |
| spellingShingle | Zhixin Lyu Atsushi Yahashiri Xinxing Yang Joshua W. McCausland Gabriela M. Kaus Ryan McQuillen David S. Weiss Jie Xiao FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli Nature Communications |
| title | FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli |
| title_full | FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli |
| title_fullStr | FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli |
| title_full_unstemmed | FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli |
| title_short | FtsN maintains active septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthases in E. coli |
| title_sort | ftsn maintains active septal cell wall synthesis by forming a processive complex with the septum specific peptidoglycan synthases in e coli |
| url | https://doi.org/10.1038/s41467-022-33404-8 |
| work_keys_str_mv | AT zhixinlyu ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli AT atsushiyahashiri ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli AT xinxingyang ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli AT joshuawmccausland ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli AT gabrielamkaus ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli AT ryanmcquillen ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli AT davidsweiss ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli AT jiexiao ftsnmaintainsactiveseptalcellwallsynthesisbyformingaprocessivecomplexwiththeseptumspecificpeptidoglycansynthasesinecoli |