Synthesis and Cytotoxic Activity of a New Group of Heterocyclic Analogues of the Combretastatins

Synthesis and Cytotoxic Activity of a New Group of Heterocyclic Analogues of the Combretastatins

A series of new analogs of combretastatin A-4 (CA-4, 1) with the A or B-ring replaced by a 3-oxo-2,3-dihydrofurocoumarin or a furocoumarin residue have been designed and synthesized by employing a cross-coupling approach. All the compounds were evaluated for their cytotoxic activity with respect to...

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Bibliographic Details
Main Authors: Alla V. Lipeeva, Elvira E. Shults, Makhmut M. Shakirov, Mikhail A. Pokrovsky, Andrey G. Pokrovsky
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Molecules
Subjects:
furocoumarins
oreoselone
psoralen
Sonogashira coupling
semi-hydrogenation
combretastatins
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/19/6/7881

Internet

http://www.mdpi.com/1420-3049/19/6/7881

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