VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2

VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2

Triple-negative breast cancer (TNBC) and its recently identified subtype, quadruple negative breast cancer (QNBC), collectively account for approximately 13% of reported breast cancer cases in the United States. These aggressive forms of breast cancer are associated with poor prognoses, limited trea...

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Bibliographic Details
Main Authors: Retheesh S. Thankan, Elizabeth Thomas, Puranik Purushottamachar, David J. Weber, Vidya P. Ramamurthy, Weiliang Huang, Maureen A. Kane, Vincent C. O. Njar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
triple/quadruple negative breast cancer (TNBC/QNBC)
MNK1 and MNK2 degrader
eIF4E signaling
Synoviolin 1 (SYVN1)
VNLG-152R and deuterated analogs
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1240996/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1240996/full

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