Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction
Introduction: The article discusses the issues of the long-term glucocorticosteroid therapy in children with nephrotic syndrome that results in severe adverse side effects. Methods: This retrospective study included 89 case reports of patients with nephrotic syndrome, aged 1–18, w...
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2019-03-01
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| Series: | Research Results in Pharmacology |
| Online Access: | https://rrpharmacology.pensoft.net/article/33831/download/pdf/ |
| _version_ | 1797429017656164352 |
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| author | Galina A. Batishcheva Olga A. Zhdanova Tatyana L. Nastausheva Yury N. Chernov |
| author_facet | Galina A. Batishcheva Olga A. Zhdanova Tatyana L. Nastausheva Yury N. Chernov |
| author_sort | Galina A. Batishcheva |
| collection | DOAJ |
| description | Introduction: The article discusses the issues of the long-term glucocorticosteroid therapy in children with nephrotic syndrome that results in severe adverse side effects.
Methods: This retrospective study included 89 case reports of patients with nephrotic syndrome, aged 1–18, who received treatment at Voronezh Regional Pediatric Hospital №1 in 1999–2014. The children’s BMI Z-score was calculated from neasured height and weight. The authors considered therapeutical complications revealed through clinical-laboratory and instrumentation examination.
Results and discussion: Long-term administration of glucocorticosteroids in patients with steroid-dependent nephrotic syndrome caused overweight and obesity. The patients who had received glucocorticosteroids for 6 months prior to the examination were overweight or obese (78%), had reactive pancreatitis (72%), leukemoid reactions (67%), liver damage (50%), Cushing’s syndrome (44%), chronic gastroduodenitis (33%), hyperglycemia (11%), arterial hypertension (6%), or infectious diseases (6%). The children observed during the period of prolonged remission of nephrotic syndrome had neither overweight, nor obesity or growth failure; signs of chronic gastroduodenitis were observed in 15% of the children.
Conclusion: The long-term glucocorticosteroid therapy in children with nephrotic syndrome caused the excess body weight or obesity and gastro-intestinal disorders. So, proton pump inhibitors should be applied simultaneously with glucocorticosteroids to prevent gastro-intestinal disorders. |
| first_indexed | 2024-03-09T09:07:07Z |
| format | Article |
| id | doaj.art-7371d19ea9ca4df5b217704fcc765a2e |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:07:07Z |
| publishDate | 2019-03-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-7371d19ea9ca4df5b217704fcc765a2e2023-12-02T10:12:55ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2019-03-0151374310.3897/rrpharmacology.5.3383133831Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correctionGalina A. Batishcheva0Olga A. Zhdanova1Tatyana L. Nastausheva2Yury N. Chernov3N.N. Burdenko Voronezh State Medical UniversityN.N. Burdenko Voronezh State Medical UniversityN.N. Burdenko Voronezh State Medical UniversityN.N. Burdenko Voronezh State Medical UniversityIntroduction: The article discusses the issues of the long-term glucocorticosteroid therapy in children with nephrotic syndrome that results in severe adverse side effects. Methods: This retrospective study included 89 case reports of patients with nephrotic syndrome, aged 1–18, who received treatment at Voronezh Regional Pediatric Hospital №1 in 1999–2014. The children’s BMI Z-score was calculated from neasured height and weight. The authors considered therapeutical complications revealed through clinical-laboratory and instrumentation examination. Results and discussion: Long-term administration of glucocorticosteroids in patients with steroid-dependent nephrotic syndrome caused overweight and obesity. The patients who had received glucocorticosteroids for 6 months prior to the examination were overweight or obese (78%), had reactive pancreatitis (72%), leukemoid reactions (67%), liver damage (50%), Cushing’s syndrome (44%), chronic gastroduodenitis (33%), hyperglycemia (11%), arterial hypertension (6%), or infectious diseases (6%). The children observed during the period of prolonged remission of nephrotic syndrome had neither overweight, nor obesity or growth failure; signs of chronic gastroduodenitis were observed in 15% of the children. Conclusion: The long-term glucocorticosteroid therapy in children with nephrotic syndrome caused the excess body weight or obesity and gastro-intestinal disorders. So, proton pump inhibitors should be applied simultaneously with glucocorticosteroids to prevent gastro-intestinal disorders.https://rrpharmacology.pensoft.net/article/33831/download/pdf/ |
| spellingShingle | Galina A. Batishcheva Olga A. Zhdanova Tatyana L. Nastausheva Yury N. Chernov Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction Research Results in Pharmacology |
| title | Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction |
| title_full | Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction |
| title_fullStr | Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction |
| title_full_unstemmed | Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction |
| title_short | Characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction |
| title_sort | characteristics of adverse side effects of corticosteroid therapy in children with nephrotic syndrome and methods of pharmacological correction |
| url | https://rrpharmacology.pensoft.net/article/33831/download/pdf/ |
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