B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV

Polvere et al. investigate B cell responses after SARS-CoV-2 vaccination in people living with HIV undergoing anti-retroviral therapy. Spike-specific humoral and B cell responses persist for at least six months although a reduced ACE2/RBD binding inhibition capacity and different memory B phenotypes...

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Main Authors: Jacopo Polvere, Massimiliano Fabbiani, Gabiria Pastore, Ilaria Rancan, Barbara Rossetti, Miriam Durante, Sara Zirpoli, Enrico Morelli, Elena Pettini, Simone Lucchesi, Fabio Fiorino, Mario Tumbarello, Annalisa Ciabattini, Francesca Montagnani, Donata Medaglini
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-023-00245-5
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author Jacopo Polvere
Massimiliano Fabbiani
Gabiria Pastore
Ilaria Rancan
Barbara Rossetti
Miriam Durante
Sara Zirpoli
Enrico Morelli
Elena Pettini
Simone Lucchesi
Fabio Fiorino
Mario Tumbarello
Annalisa Ciabattini
Francesca Montagnani
Donata Medaglini
author_facet Jacopo Polvere
Massimiliano Fabbiani
Gabiria Pastore
Ilaria Rancan
Barbara Rossetti
Miriam Durante
Sara Zirpoli
Enrico Morelli
Elena Pettini
Simone Lucchesi
Fabio Fiorino
Mario Tumbarello
Annalisa Ciabattini
Francesca Montagnani
Donata Medaglini
author_sort Jacopo Polvere
collection DOAJ
description Polvere et al. investigate B cell responses after SARS-CoV-2 vaccination in people living with HIV undergoing anti-retroviral therapy. Spike-specific humoral and B cell responses persist for at least six months although a reduced ACE2/RBD binding inhibition capacity and different memory B phenotypes are observed compared to healthy controls.
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spelling doaj.art-73720c84f14541f9b1f7b7ba2b9138792023-02-05T12:22:04ZengNature PortfolioCommunications Medicine2730-664X2023-01-013111010.1038/s43856-023-00245-5B cell response after SARS-CoV-2 mRNA vaccination in people living with HIVJacopo Polvere0Massimiliano Fabbiani1Gabiria Pastore2Ilaria Rancan3Barbara Rossetti4Miriam Durante5Sara Zirpoli6Enrico Morelli7Elena Pettini8Simone Lucchesi9Fabio Fiorino10Mario Tumbarello11Annalisa Ciabattini12Francesca Montagnani13Donata Medaglini14Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaDepartment of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of SienaLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaDepartment of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of SienaDepartment of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of SienaDepartment of Medical Biotechnologies, University of SienaLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaDepartment of Medical Biotechnologies, University of SienaLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaDepartment of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of SienaLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaDepartment of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of SienaLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of SienaPolvere et al. investigate B cell responses after SARS-CoV-2 vaccination in people living with HIV undergoing anti-retroviral therapy. Spike-specific humoral and B cell responses persist for at least six months although a reduced ACE2/RBD binding inhibition capacity and different memory B phenotypes are observed compared to healthy controls.https://doi.org/10.1038/s43856-023-00245-5
spellingShingle Jacopo Polvere
Massimiliano Fabbiani
Gabiria Pastore
Ilaria Rancan
Barbara Rossetti
Miriam Durante
Sara Zirpoli
Enrico Morelli
Elena Pettini
Simone Lucchesi
Fabio Fiorino
Mario Tumbarello
Annalisa Ciabattini
Francesca Montagnani
Donata Medaglini
B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV
Communications Medicine
title B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV
title_full B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV
title_fullStr B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV
title_full_unstemmed B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV
title_short B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV
title_sort b cell response after sars cov 2 mrna vaccination in people living with hiv
url https://doi.org/10.1038/s43856-023-00245-5
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