Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors

Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors

Abstract Background As the most lethal gynecologic cancer, ovarian cancer (OV) holds the potential of being immunotherapy-responsive. However, only modest therapeutic effects have been achieved by immunotherapies such as immune checkpoint blockade. This study aims to propose a generalized stroma-imm...

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Bibliographic Details
Main Authors: Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li, Chuang-Hua Luo, Lan-Yue Cui, Li-Chao Li, Ying Xiao, Xian-Ying Zhu, Hai-Liang Zhang, Gong-Kan Feng, Guo-Chen Liu, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
Ovarian cancer
Immunotherapy
Stroma
Prognostic signature
Online Access:https://doi.org/10.1186/s12967-023-04422-x

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