Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Soluplus<sup>®</sup> Polymeric Micelles Encapsulating Fenbendazole

Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Soluplus<sup>®</sup> Polymeric Micelles Encapsulating Fenbendazole

Fenbendazole (FEN), a broad-spectrum benzimidazole anthelmintic, suppresses cancer cell growth through various mechanisms but has low solubility and achieves low blood concentrations, which leads to low bioavailability. Solubilizing agents are required to prepare poorly soluble drugs for injections;...

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Bibliographic Details
Main Authors: Ik Sup Jin, Min Jeong Jo, Chun-Woong Park, Youn Bok Chung, Jin-Seok Kim, Dae Hwan Shin
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceutics
Subjects:
fenbendazole
micelle solubilization
pharmacokinetics
Soluplus<sup>®</sup> polymeric micelles
toxicity test
Online Access:https://www.mdpi.com/1999-4923/12/10/1000

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