Prevalence of 7q deletion in patients with Acute myeloid leukemia .
Introduction: Deletion of critical regions on long arm of chromosome 7 is important in pathogenesis of acute myeloid leukemia (AML). These regions include 7q22 and 7q31 which carry certain tumor suppressor genes which if deleted can result in uncontrolled division of myeloid cells. Aims: To est...
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| Format: | Article |
| Language: | English |
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Prathima Institute of Medical Sciences
2020-08-01
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| Series: | Perspectives In Medical Research |
| Subjects: | |
| Online Access: | https://www.pimr.org.in/2020-vol8-issue-2/originalarticle1_v1.pdf |
| _version_ | 1797462457585762304 |
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| author | Anjali Shastry1 , Amudha Subramaniam1 , Preetha Tilak2 |
| author_facet | Anjali Shastry1 , Amudha Subramaniam1 , Preetha Tilak2 |
| author_sort | Anjali Shastry1 , Amudha Subramaniam1 , Preetha Tilak2 |
| collection | DOAJ |
| description | Introduction: Deletion of critical regions on long arm of
chromosome 7 is important in pathogenesis of acute myeloid
leukemia (AML). These regions include 7q22 and 7q31 which
carry certain tumor suppressor genes which if deleted can
result in uncontrolled division of myeloid cells.
Aims: To estimate prevalence of 7q deletion in patients with
acute myeloid leukemia (AML).
Materials and methods: Retrospective study was done on 25
bone marrow samples diagnosed with Acute myeloid leukemia
referred to Division of Human Genetics St.John’s Medical
college, Bangalore. Samples were subjected to standard
protocol for karyotyping and FISH. Percentage of patients who
were positive for 7q deletion was calculated.
Results: Out of 25 samples, 5 samples were positive for 7 q
deletion accounting to 20% of total patients diagnosed with
AML.
Conclusion: Presence of 7q deletion can be a poor prognostic
marker since tumour suppressor genes are present in these
regions. Hence cytogenetic markers are very important in
deciding treatment and prognosis in these patients. |
| first_indexed | 2024-03-09T17:36:53Z |
| format | Article |
| id | doaj.art-7374a9553fd24adf9db0bd91ff9941ed |
| institution | Directory Open Access Journal |
| issn | 2348-1447 2348-229X |
| language | English |
| last_indexed | 2024-03-09T17:36:53Z |
| publishDate | 2020-08-01 |
| publisher | Prathima Institute of Medical Sciences |
| record_format | Article |
| series | Perspectives In Medical Research |
| spelling | doaj.art-7374a9553fd24adf9db0bd91ff9941ed2023-11-24T11:52:42ZengPrathima Institute of Medical SciencesPerspectives In Medical Research2348-14472348-229X2020-08-01827910.47799/pimr.0802.04Prevalence of 7q deletion in patients with Acute myeloid leukemia .Anjali Shastry1 , Amudha Subramaniam1 , Preetha Tilak201. Tutor, Division of Human Genetics, Department of Anatomy, St.John’s Medical college, Bangalore-34 2. Junior consultant, Division of Human Genetics, Department of Anatomy ,St.John’s Medical college, Bangalore-34 corresponding author: Anjali Shastry , Division of Human Genetics, Department of Anatomy, St.John’s Medical college, Bangalore-34 mobile :9008735895 E-mail address: anju_shas@yahoo.comIntroduction: Deletion of critical regions on long arm of chromosome 7 is important in pathogenesis of acute myeloid leukemia (AML). These regions include 7q22 and 7q31 which carry certain tumor suppressor genes which if deleted can result in uncontrolled division of myeloid cells. Aims: To estimate prevalence of 7q deletion in patients with acute myeloid leukemia (AML). Materials and methods: Retrospective study was done on 25 bone marrow samples diagnosed with Acute myeloid leukemia referred to Division of Human Genetics St.John’s Medical college, Bangalore. Samples were subjected to standard protocol for karyotyping and FISH. Percentage of patients who were positive for 7q deletion was calculated. Results: Out of 25 samples, 5 samples were positive for 7 q deletion accounting to 20% of total patients diagnosed with AML. Conclusion: Presence of 7q deletion can be a poor prognostic marker since tumour suppressor genes are present in these regions. Hence cytogenetic markers are very important in deciding treatment and prognosis in these patients.https://www.pimr.org.in/2020-vol8-issue-2/originalarticle1_v1.pdf7q deletionacute myeloid leukemiafishkaryotyping |
| spellingShingle | Anjali Shastry1 , Amudha Subramaniam1 , Preetha Tilak2 Prevalence of 7q deletion in patients with Acute myeloid leukemia . Perspectives In Medical Research 7q deletion acute myeloid leukemia fish karyotyping |
| title | Prevalence of 7q deletion in patients with Acute myeloid leukemia . |
| title_full | Prevalence of 7q deletion in patients with Acute myeloid leukemia . |
| title_fullStr | Prevalence of 7q deletion in patients with Acute myeloid leukemia . |
| title_full_unstemmed | Prevalence of 7q deletion in patients with Acute myeloid leukemia . |
| title_short | Prevalence of 7q deletion in patients with Acute myeloid leukemia . |
| title_sort | prevalence of 7q deletion in patients with acute myeloid leukemia |
| topic | 7q deletion acute myeloid leukemia fish karyotyping |
| url | https://www.pimr.org.in/2020-vol8-issue-2/originalarticle1_v1.pdf |
| work_keys_str_mv | AT anjalishastry1amudhasubramaniam1preethatilak2 prevalenceof7qdeletioninpatientswithacutemyeloidleukemia |