Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands.
Ticks that feed on vertebrate hosts use their salivary secretion, which contains various bioactive components, to manipulate the host's responses. The mechanisms controlling the tick salivary gland in this dynamic process are not well understood. We identified the tick D1 receptor activated by...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3031531?pdf=render |
| _version_ | 1818254635840831488 |
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| author | Ladislav Šimo Juraj Koči Dušan Žitňan Yoonseong Park |
| author_facet | Ladislav Šimo Juraj Koči Dušan Žitňan Yoonseong Park |
| author_sort | Ladislav Šimo |
| collection | DOAJ |
| description | Ticks that feed on vertebrate hosts use their salivary secretion, which contains various bioactive components, to manipulate the host's responses. The mechanisms controlling the tick salivary gland in this dynamic process are not well understood. We identified the tick D1 receptor activated by dopamine, a potent inducer of the salivary secretion of ticks. Temporal and spatial expression patterns examined by immunohistochemistry and reverse transcription polymerase chain reaction suggest that the dopamine produced in the basal cells of salivary gland acini is secreted into the lumen and activates the D1 receptors on the luminal surface of the cells lining the acini. Therefore, we propose a paracrine function of dopamine that is mediated by the D1 receptor in the salivary gland at an early phase of feeding. The molecular and pharmacological characterization of the D1 receptor in this study provides the foundation for understanding the functions of dopamine in the blood-feeding of ticks. |
| first_indexed | 2024-12-12T16:59:06Z |
| format | Article |
| id | doaj.art-737582d1dbbc4542ae951fc7ac971adb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T16:59:06Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-737582d1dbbc4542ae951fc7ac971adb2022-12-22T00:18:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1615810.1371/journal.pone.0016158Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands.Ladislav ŠimoJuraj KočiDušan ŽitňanYoonseong ParkTicks that feed on vertebrate hosts use their salivary secretion, which contains various bioactive components, to manipulate the host's responses. The mechanisms controlling the tick salivary gland in this dynamic process are not well understood. We identified the tick D1 receptor activated by dopamine, a potent inducer of the salivary secretion of ticks. Temporal and spatial expression patterns examined by immunohistochemistry and reverse transcription polymerase chain reaction suggest that the dopamine produced in the basal cells of salivary gland acini is secreted into the lumen and activates the D1 receptors on the luminal surface of the cells lining the acini. Therefore, we propose a paracrine function of dopamine that is mediated by the D1 receptor in the salivary gland at an early phase of feeding. The molecular and pharmacological characterization of the D1 receptor in this study provides the foundation for understanding the functions of dopamine in the blood-feeding of ticks.http://europepmc.org/articles/PMC3031531?pdf=render |
| spellingShingle | Ladislav Šimo Juraj Koči Dušan Žitňan Yoonseong Park Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. PLoS ONE |
| title | Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. |
| title_full | Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. |
| title_fullStr | Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. |
| title_full_unstemmed | Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. |
| title_short | Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. |
| title_sort | evidence for d1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands |
| url | http://europepmc.org/articles/PMC3031531?pdf=render |
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