Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study
Abstract Gallstone disease (GSD) is thought to be associated with the risk of coronary heart disease (CHD) or acute myocardial infarction (AMI), which may be due to abnormal cholesterol metabolism. We used multiple Mendelian randomization (MR) methods based on publicly available genome-wide associat...
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| Format: | Article |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46117-9 |
| _version_ | 1797636900483235840 |
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| author | Qingan Fu Tianzhou Shen Qingyun Yu Long Jiang Renqiang Yang |
| author_facet | Qingan Fu Tianzhou Shen Qingyun Yu Long Jiang Renqiang Yang |
| author_sort | Qingan Fu |
| collection | DOAJ |
| description | Abstract Gallstone disease (GSD) is thought to be associated with the risk of coronary heart disease (CHD) or acute myocardial infarction (AMI), which may be due to abnormal cholesterol metabolism. We used multiple Mendelian randomization (MR) methods based on publicly available genome-wide association study data to assess whether this association is genetically causal and to search for loci driving causality. Pooled data for GSD were obtained from FinnGen Biobank and Biobank Japan, while CHD and AMI were obtained as pooled data from the CARDIoGRAMplusC4D consortium. In this MR study, we found a significant negative causal effect of genetic susceptibility to GSD on AMI in the Finnish population, but no causal effect was found on CHD. This causal effect was not confounded by reverse causality and the same findings were obtained in the Japanese population. Furthermore, the negative causal effect of GSD on AMI risk may be driven by the rs4245791-regulated ABCG5/8 protein. In conclusion, the results of this MR study support a negative causal effect of GSD on AMI and suggest that rs4245791 is the causal driver locus of this effect, which provides new ideas and evidence for the prevention and etiologic study of AMI in patients with GSD. |
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| format | Article |
| id | doaj.art-7375c2633d744a2aa4b32a24ce149b83 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T12:41:46Z |
| publishDate | 2023-11-01 |
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| spelling | doaj.art-7375c2633d744a2aa4b32a24ce149b832023-11-05T12:17:21ZengNature PortfolioScientific Reports2045-23222023-11-0113111010.1038/s41598-023-46117-9Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization studyQingan Fu0Tianzhou Shen1Qingyun Yu2Long Jiang3Renqiang Yang4Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityAbstract Gallstone disease (GSD) is thought to be associated with the risk of coronary heart disease (CHD) or acute myocardial infarction (AMI), which may be due to abnormal cholesterol metabolism. We used multiple Mendelian randomization (MR) methods based on publicly available genome-wide association study data to assess whether this association is genetically causal and to search for loci driving causality. Pooled data for GSD were obtained from FinnGen Biobank and Biobank Japan, while CHD and AMI were obtained as pooled data from the CARDIoGRAMplusC4D consortium. In this MR study, we found a significant negative causal effect of genetic susceptibility to GSD on AMI in the Finnish population, but no causal effect was found on CHD. This causal effect was not confounded by reverse causality and the same findings were obtained in the Japanese population. Furthermore, the negative causal effect of GSD on AMI risk may be driven by the rs4245791-regulated ABCG5/8 protein. In conclusion, the results of this MR study support a negative causal effect of GSD on AMI and suggest that rs4245791 is the causal driver locus of this effect, which provides new ideas and evidence for the prevention and etiologic study of AMI in patients with GSD.https://doi.org/10.1038/s41598-023-46117-9 |
| spellingShingle | Qingan Fu Tianzhou Shen Qingyun Yu Long Jiang Renqiang Yang Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study Scientific Reports |
| title | Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study |
| title_full | Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study |
| title_fullStr | Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study |
| title_full_unstemmed | Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study |
| title_short | Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study |
| title_sort | causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction a mendelian randomization study |
| url | https://doi.org/10.1038/s41598-023-46117-9 |
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