Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe
In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad sil...
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MDPI AG
2018-04-01
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| Online Access: | http://www.mdpi.com/1424-8220/18/5/1361 |
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| author | Robert Bogdanowicz Paweł Niedziałkowski Michał Sobaszek Dariusz Burnat Wioleta Białobrzeska Zofia Cebula Petr Sezemsky Marcin Koba Vitezslav Stranak Tadeusz Ossowski Mateusz Śmietana |
| author_facet | Robert Bogdanowicz Paweł Niedziałkowski Michał Sobaszek Dariusz Burnat Wioleta Białobrzeska Zofia Cebula Petr Sezemsky Marcin Koba Vitezslav Stranak Tadeusz Ossowski Mateusz Śmietana |
| author_sort | Robert Bogdanowicz |
| collection | DOAJ |
| description | In this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg−1·L) and 16,400 a.u./M (a.u.·mg−1·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL−1, and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds. |
| first_indexed | 2024-04-13T06:24:44Z |
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| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T06:24:44Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-737bdb03c0ed4772a96e214c0cd58d3a2022-12-22T02:58:28ZengMDPI AGSensors1424-82202018-04-01185136110.3390/s18051361s18051361Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber ProbeRobert Bogdanowicz0Paweł Niedziałkowski1Michał Sobaszek2Dariusz Burnat3Wioleta Białobrzeska4Zofia Cebula5Petr Sezemsky6Marcin Koba7Vitezslav Stranak8Tadeusz Ossowski9Mateusz Śmietana10Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, PolandDepartment of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandFaculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, PolandInstitute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warszawa, PolandDepartment of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandDepartment of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandInstitute of Physics and Biophysics, Faculty of Science, University of South Bohemia, Branisovska 1760, 370 05 Ceske Budejovice, Czech RepublicInstitute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warszawa, PolandInstitute of Physics and Biophysics, Faculty of Science, University of South Bohemia, Branisovska 1760, 370 05 Ceske Budejovice, Czech RepublicDepartment of Analytical Chemistry, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandInstitute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warszawa, PolandIn this work an application of optical fiber sensors for real-time optical monitoring of electrochemical deposition of ketoprofen during its anodic oxidation is discussed. The sensors were fabricated by reactive magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. ITO tuned in optical properties and thickness allows for achieving a lossy-mode resonance (LMR) phenomenon and it can be simultaneously applied as an electrode in an electrochemical setup. The ITO-LMR electrode allows for optical monitoring of changes occurring at the electrode during electrochemical processing. The studies have shown that the ITO-LMR sensor’s spectral response strongly depends on electrochemical modification of its surface by ketoprofen. The effect can be applied for real-time detection of ketoprofen. The obtained sensitivities reached over 1400 nm/M (nm·mg−1·L) and 16,400 a.u./M (a.u.·mg−1·L) for resonance wavelength and transmission shifts, respectively. The proposed method is a valuable alternative for the analysis of ketoprofen within the concentration range of 0.25–250 μg mL−1, and allows for its determination at therapeutic and toxic levels. The proposed novel sensing approach provides a promising strategy for both optical and electrochemical detection of electrochemical modifications of ITO or its surface by various compounds.http://www.mdpi.com/1424-8220/18/5/1361ketoprofenanti-inflammatory drugdrug analysisoptical fiber sensorreactive magnetron sputtering thin filmindium tin oxide (ITO)lossy-mode resonance (LMR)electrochemistryelectropolymerization |
| spellingShingle | Robert Bogdanowicz Paweł Niedziałkowski Michał Sobaszek Dariusz Burnat Wioleta Białobrzeska Zofia Cebula Petr Sezemsky Marcin Koba Vitezslav Stranak Tadeusz Ossowski Mateusz Śmietana Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe Sensors ketoprofen anti-inflammatory drug drug analysis optical fiber sensor reactive magnetron sputtering thin film indium tin oxide (ITO) lossy-mode resonance (LMR) electrochemistry electropolymerization |
| title | Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe |
| title_full | Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe |
| title_fullStr | Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe |
| title_full_unstemmed | Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe |
| title_short | Optical Detection of Ketoprofen by Its Electropolymerization on an Indium Tin Oxide-Coated Optical Fiber Probe |
| title_sort | optical detection of ketoprofen by its electropolymerization on an indium tin oxide coated optical fiber probe |
| topic | ketoprofen anti-inflammatory drug drug analysis optical fiber sensor reactive magnetron sputtering thin film indium tin oxide (ITO) lossy-mode resonance (LMR) electrochemistry electropolymerization |
| url | http://www.mdpi.com/1424-8220/18/5/1361 |
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