ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSION
The repeated experience of winning in a social conflict setting elevates levels of aggression and may lead to violent behavioral patterns. Here we use a paradigm of repeated aggression and fighting deprivation to examine changes in behavior, neurogenesis, and neuronal activity in mice with positive...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-12-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00443/full |
| _version_ | 1819089172880687104 |
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| author | Dmitriy eSmagin Dmitriy eSmagin Dmitriy eSmagin June-Hee ePark Tatyana eMichurina Tatyana eMichurina Tatyana eMichurina Tatyana eMichurina Natalia ePeunova Natalia ePeunova Natalia ePeunova Zachary eGlass Kasim eSayed Natalia eBondar Irina eKovalenko Natalia N Kudryavtseva Grigori eEnikolopov Grigori eEnikolopov Grigori eEnikolopov Grigori eEnikolopov |
| author_facet | Dmitriy eSmagin Dmitriy eSmagin Dmitriy eSmagin June-Hee ePark Tatyana eMichurina Tatyana eMichurina Tatyana eMichurina Tatyana eMichurina Natalia ePeunova Natalia ePeunova Natalia ePeunova Zachary eGlass Kasim eSayed Natalia eBondar Irina eKovalenko Natalia N Kudryavtseva Grigori eEnikolopov Grigori eEnikolopov Grigori eEnikolopov Grigori eEnikolopov |
| author_sort | Dmitriy eSmagin |
| collection | DOAJ |
| description | The repeated experience of winning in a social conflict setting elevates levels of aggression and may lead to violent behavioral patterns. Here we use a paradigm of repeated aggression and fighting deprivation to examine changes in behavior, neurogenesis, and neuronal activity in mice with positive fighting experience. We show that for males, repeated positive fighting experience induces persistent demonstration of aggression and stereotypic behaviors in daily agonistic interactions, enhances aggressive motivation, and elevates levels of anxiety. When winning males are deprived of opportunities to engage in further fights, they demonstrate increased levels of aggressiveness. Positive fighting experience results in increased levels of progenitor cell proliferation and production of young neurons in the hippocampus. This increase is not diminished after a fighting deprivation period. Furthermore, repeated winning experience decreases the number of activated (c-fos positive) cells in the basolateral amygdala and increases the number of activated cells in the hippocampus; a subsequent no-fight period restores the number of c-fos-positive cells. Our results indicate that extended positive fighting experience in a social conflict heightens aggression, increases proliferation of neuronal progenitors and production of young neurons in the hippocampus, and decreases neuronal activity in the amygdala; these changes can be modified by depriving the winners of the opportunity for further fights. |
| first_indexed | 2024-12-21T22:03:43Z |
| format | Article |
| id | doaj.art-737c0e64e48348d78820496bb96bb249 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-21T22:03:43Z |
| publishDate | 2015-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-737c0e64e48348d78820496bb96bb2492022-12-21T18:48:46ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-12-01910.3389/fnins.2015.00443160544ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSIONDmitriy eSmagin0Dmitriy eSmagin1Dmitriy eSmagin2June-Hee ePark3Tatyana eMichurina4Tatyana eMichurina5Tatyana eMichurina6Tatyana eMichurina7Natalia ePeunova8Natalia ePeunova9Natalia ePeunova10Zachary eGlass11Kasim eSayed12Natalia eBondar13Irina eKovalenko14Natalia N Kudryavtseva15Grigori eEnikolopov16Grigori eEnikolopov17Grigori eEnikolopov18Grigori eEnikolopov19Cold Spring Harbor LaboratoryMoscow Institute of Physics and TechnologyInstitute of Cytology and Genetics SD RASCold Spring Harbor LaboratoryCold Spring Harbor LaboratoryMoscow Institute of Physics and TechnologyStony Brook School of MedicineStony Brook UniversityCold Spring Harbor LaboratoryStony Brook School of MedicineStony Brook UniversityCold Spring Harbor LaboratoryCold Spring Harbor LaboratoryInstitute of Cytology and Genetics SD RASInstitute of Cytology and Genetics SD RASInstitute of Cytology and Genetics SD RASCold Spring Harbor LaboratoryMoscow Institute of Physics and TechnologyStony Brook School of MedicineStony Brook UniversityThe repeated experience of winning in a social conflict setting elevates levels of aggression and may lead to violent behavioral patterns. Here we use a paradigm of repeated aggression and fighting deprivation to examine changes in behavior, neurogenesis, and neuronal activity in mice with positive fighting experience. We show that for males, repeated positive fighting experience induces persistent demonstration of aggression and stereotypic behaviors in daily agonistic interactions, enhances aggressive motivation, and elevates levels of anxiety. When winning males are deprived of opportunities to engage in further fights, they demonstrate increased levels of aggressiveness. Positive fighting experience results in increased levels of progenitor cell proliferation and production of young neurons in the hippocampus. This increase is not diminished after a fighting deprivation period. Furthermore, repeated winning experience decreases the number of activated (c-fos positive) cells in the basolateral amygdala and increases the number of activated cells in the hippocampus; a subsequent no-fight period restores the number of c-fos-positive cells. Our results indicate that extended positive fighting experience in a social conflict heightens aggression, increases proliferation of neuronal progenitors and production of young neurons in the hippocampus, and decreases neuronal activity in the amygdala; these changes can be modified by depriving the winners of the opportunity for further fights.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00443/fullAggressionAmygdalaAnxietyHippocampusautismstress |
| spellingShingle | Dmitriy eSmagin Dmitriy eSmagin Dmitriy eSmagin June-Hee ePark Tatyana eMichurina Tatyana eMichurina Tatyana eMichurina Tatyana eMichurina Natalia ePeunova Natalia ePeunova Natalia ePeunova Zachary eGlass Kasim eSayed Natalia eBondar Irina eKovalenko Natalia N Kudryavtseva Grigori eEnikolopov Grigori eEnikolopov Grigori eEnikolopov Grigori eEnikolopov ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSION Frontiers in Neuroscience Aggression Amygdala Anxiety Hippocampus autism stress |
| title | ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSION |
| title_full | ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSION |
| title_fullStr | ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSION |
| title_full_unstemmed | ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSION |
| title_short | ALTERED HIPPOCAMPAL NEUROGENESIS AND AMYGDALAR NEURONAL ACTIVITY IN ADULT MICE WITH REPEATED EXPERIENCE OF AGGRESSION |
| title_sort | altered hippocampal neurogenesis and amygdalar neuronal activity in adult mice with repeated experience of aggression |
| topic | Aggression Amygdala Anxiety Hippocampus autism stress |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00443/full |
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