TCF7L1 Regulates <i>LGR5</i> Expression in Colorectal Cancer Cells

TCF7L1 Regulates <i>LGR5</i> Expression in Colorectal Cancer Cells

Mutations in components of the Wnt/β-catenin signaling pathway drive colorectal cancer (CRC), in part, by deregulating expression of genes controlled by the T-cell factor (TCF) family of transcription factors. TCFs contain a conserved DNA binding domain that mediates association with TCF binding ele...

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Bibliographic Details
Main Authors:	Carli M. King, Olivia M. Marx, Wei Ding, Walter A. Koltun, Gregory S. Yochum
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Genes
Subjects:	colorectal cancer LGR5 spheroids T-cell factors TCF7L1 WNT
Online Access:	https://www.mdpi.com/2073-4425/14/2/481

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