Cell–Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis

Cell–Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis

Fibronectin is essential for somite formation in the vertebrate embryo. Fibronectin matrix assembly starts as cells emerge from the primitive streak and ingress in the unsegmented presomitic mesoderm (PSM). PSM cells undergo cyclic waves of segmentation clock gene expression, followed by Notch-depen...

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Bibliographic Details
Main Authors: Patrícia Gomes de Almeida, Pedro Rifes, Ana P. Martins-Jesus, Gonçalo G. Pinheiro, Raquel P. Andrade, Sólveig Thorsteinsdóttir
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
fibronectin
fibronectin matrix assembly
actomyosin contractility
somitogenesis
segmentation clock
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Online Access:https://www.mdpi.com/2073-4409/11/13/2003

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