Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
Abdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expres...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17883-1 |
| _version_ | 1818842025087205376 |
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| author | Deshka S. Foster Clement D. Marshall Gunsagar S. Gulati Malini S. Chinta Alan Nguyen Ankit Salhotra R. Ellen Jones Austin Burcham Tristan Lerbs Lu Cui Megan E. King Ashley L. Titan R. Chase Ransom Anoop Manjunath Michael S. Hu Charles P. Blackshear Shamik Mascharak Alessandra L. Moore Jeffrey A. Norton Cindy J. Kin Andrew A. Shelton Michael Januszyk Geoffrey C. Gurtner Gerlinde Wernig Michael T. Longaker |
| author_facet | Deshka S. Foster Clement D. Marshall Gunsagar S. Gulati Malini S. Chinta Alan Nguyen Ankit Salhotra R. Ellen Jones Austin Burcham Tristan Lerbs Lu Cui Megan E. King Ashley L. Titan R. Chase Ransom Anoop Manjunath Michael S. Hu Charles P. Blackshear Shamik Mascharak Alessandra L. Moore Jeffrey A. Norton Cindy J. Kin Andrew A. Shelton Michael Januszyk Geoffrey C. Gurtner Gerlinde Wernig Michael T. Longaker |
| author_sort | Deshka S. Foster |
| collection | DOAJ |
| description | Abdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expression promote adhesions, and JUN suppression can prevent adhesion formation. |
| first_indexed | 2024-12-19T04:35:24Z |
| format | Article |
| id | doaj.art-737d1dd933494725beaf1af250bea456 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:35:24Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-737d1dd933494725beaf1af250bea4562022-12-21T20:35:46ZengNature PortfolioNature Communications2041-17232020-08-0111111810.1038/s41467-020-17883-1Elucidating the fundamental fibrotic processes driving abdominal adhesion formationDeshka S. Foster0Clement D. Marshall1Gunsagar S. Gulati2Malini S. Chinta3Alan Nguyen4Ankit Salhotra5R. Ellen Jones6Austin Burcham7Tristan Lerbs8Lu Cui9Megan E. King10Ashley L. Titan11R. Chase Ransom12Anoop Manjunath13Michael S. Hu14Charles P. Blackshear15Shamik Mascharak16Alessandra L. Moore17Jeffrey A. Norton18Cindy J. Kin19Andrew A. Shelton20Michael Januszyk21Geoffrey C. Gurtner22Gerlinde Wernig23Michael T. Longaker24Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineDepartment of Surgery, Stanford University School of MedicineDepartment of Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of MedicineHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Stanford University School of MedicineAbdominal adhesions are a common cause of bowel obstruction, but knowledge regarding adhesion biology and anti-adhesion therapies remains limited. Here the authors report a systematic analysis of mouse and human adhesion tissues demonstrating that visceral fibroblast JUN and associated PDGFRA expression promote adhesions, and JUN suppression can prevent adhesion formation.https://doi.org/10.1038/s41467-020-17883-1 |
| spellingShingle | Deshka S. Foster Clement D. Marshall Gunsagar S. Gulati Malini S. Chinta Alan Nguyen Ankit Salhotra R. Ellen Jones Austin Burcham Tristan Lerbs Lu Cui Megan E. King Ashley L. Titan R. Chase Ransom Anoop Manjunath Michael S. Hu Charles P. Blackshear Shamik Mascharak Alessandra L. Moore Jeffrey A. Norton Cindy J. Kin Andrew A. Shelton Michael Januszyk Geoffrey C. Gurtner Gerlinde Wernig Michael T. Longaker Elucidating the fundamental fibrotic processes driving abdominal adhesion formation Nature Communications |
| title | Elucidating the fundamental fibrotic processes driving abdominal adhesion formation |
| title_full | Elucidating the fundamental fibrotic processes driving abdominal adhesion formation |
| title_fullStr | Elucidating the fundamental fibrotic processes driving abdominal adhesion formation |
| title_full_unstemmed | Elucidating the fundamental fibrotic processes driving abdominal adhesion formation |
| title_short | Elucidating the fundamental fibrotic processes driving abdominal adhesion formation |
| title_sort | elucidating the fundamental fibrotic processes driving abdominal adhesion formation |
| url | https://doi.org/10.1038/s41467-020-17883-1 |
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