Sickle Cell Disease and HIV
Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, parti...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-03-01
|
| Series: | Journal of the International Association of Providers of AIDS Care |
| Online Access: | https://doi.org/10.1177/2325957413508320 |
| _version_ | 1818619629393674240 |
|---|---|
| author | Esther Brenda Odera MBChB Charles Kwobah MBChB Geren Stone MD Faraj Some MBChB, MMED Rachel Christine Vreeman MD, MS |
| author_facet | Esther Brenda Odera MBChB Charles Kwobah MBChB Geren Stone MD Faraj Some MBChB, MMED Rachel Christine Vreeman MD, MS |
| author_sort | Esther Brenda Odera MBChB |
| collection | DOAJ |
| description | Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients. |
| first_indexed | 2024-12-16T17:40:31Z |
| format | Article |
| id | doaj.art-737e1080cad84e5fb288077615ccc399 |
| institution | Directory Open Access Journal |
| issn | 2325-9574 2325-9582 |
| language | English |
| last_indexed | 2024-12-16T17:40:31Z |
| publishDate | 2014-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of the International Association of Providers of AIDS Care |
| spelling | doaj.art-737e1080cad84e5fb288077615ccc3992022-12-21T22:22:37ZengSAGE PublishingJournal of the International Association of Providers of AIDS Care2325-95742325-95822014-03-011310.1177/2325957413508320Sickle Cell Disease and HIVEsther Brenda Odera MBChB0Charles Kwobah MBChB1Geren Stone MD2Faraj Some MBChB, MMED3Rachel Christine Vreeman MD, MS4Academic Model Providing Access to Healthcare (AMPATH), Eldoret, KenyaAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, KenyaIndiana University School of Medicine, Indianapolis, IN, USASchool of Medicine, College of Health Sciences, Moi University, Eldoret, KenyaIndiana University School of Medicine, Indianapolis, IN, USASickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients.https://doi.org/10.1177/2325957413508320 |
| spellingShingle | Esther Brenda Odera MBChB Charles Kwobah MBChB Geren Stone MD Faraj Some MBChB, MMED Rachel Christine Vreeman MD, MS Sickle Cell Disease and HIV Journal of the International Association of Providers of AIDS Care |
| title | Sickle Cell Disease and HIV |
| title_full | Sickle Cell Disease and HIV |
| title_fullStr | Sickle Cell Disease and HIV |
| title_full_unstemmed | Sickle Cell Disease and HIV |
| title_short | Sickle Cell Disease and HIV |
| title_sort | sickle cell disease and hiv |
| url | https://doi.org/10.1177/2325957413508320 |
| work_keys_str_mv | AT estherbrendaoderambchb sicklecelldiseaseandhiv AT charleskwobahmbchb sicklecelldiseaseandhiv AT gerenstonemd sicklecelldiseaseandhiv AT farajsomembchbmmed sicklecelldiseaseandhiv AT rachelchristinevreemanmdms sicklecelldiseaseandhiv |