Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changes
Abstract Background The purpose of this study was to compare the dosimetric characteristics of five different treatment planning techniques for locally advanced non‐small cell lung cancer (LA‐NSCLC) with sequential plan changes. Methods A total of 13 stage III NSCLC patients were enrolled in this st...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.15137 |
| _version_ | 1797391514348814336 |
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| author | Masahide Saito Takafumi Komiyama Kan Marino Shinichi Aoki Tomoko Akita Masaki Matsuda Naoki Sano Hidekazu Suzuki Ueda Koji Hikaru Nemoto Hiroshi Onishi |
| author_facet | Masahide Saito Takafumi Komiyama Kan Marino Shinichi Aoki Tomoko Akita Masaki Matsuda Naoki Sano Hidekazu Suzuki Ueda Koji Hikaru Nemoto Hiroshi Onishi |
| author_sort | Masahide Saito |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to compare the dosimetric characteristics of five different treatment planning techniques for locally advanced non‐small cell lung cancer (LA‐NSCLC) with sequential plan changes. Methods A total of 13 stage III NSCLC patients were enrolled in this study. These patients had both computed tomography (CT) images for initial and boost treatment plans. The latter CT images were taken if tumor shrinkage was observed after 2 weeks of treatment. The prescription dose was 60 Gy/30 Fr (initial: 40 Gy/20 Fr, and boost: 20 Gy/10 Fr). Five techniques (forward‐planed 3‐dimensional conformal radiotherapy [F‐3DCRT] on both CT images, inverse‐planned 3DCRT [I‐3DCRT] on both CT images, volumetric modulated arc therapy [VMAT] on both CT images, F‐3DCRT on initial CT plus VMAT on boost CT [bVMAT], and hybrid of fixed intensity‐modulated radiotherapy [IMRT] beams and VMAT beams on both CT images [hybrid]) were recalculated for all patients. The accumulated doses between initial and boost plans were compared among all treatment techniques. Results The conformity indexes (CI) of the planning target volume (PTV) of the five planning techniques were 0.34 ± 0.10, 0.57 ± 0.10, 0.86 ± 0.08, 0.61 ± 0.12, and 0.83 ± 0.11 for F‐3DCRT, I‐3DCRT, VMAT, bVMAT, and hybrid, respectively. In the same manner, lung volumes receiving >20 Gy (V20Gy) were 21.05 ± 10.56%, 20.86 ± 6.45, 19.50 ± 7.38%, 19.98 ± 10.04%, and 17.74 ± 7.86%. There was significant improvement about CI and V20Gy for hybrid compared with F‐3DCRT (p < 0.05). Conclusion The IMRT/VMAT hybrid technique for LA‐NSCLC patients improved target CI and reduced lung doses. Furthermore, if IMRT was not available initially, starting with 3DCRT might be beneficial as demonstrated in the bVMAT procedure of this study. |
| first_indexed | 2024-03-08T23:33:35Z |
| format | Article |
| id | doaj.art-7382063601f0446abacc90c6765e7586 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-08T23:33:35Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-7382063601f0446abacc90c6765e75862023-12-14T08:45:41ZengWileyThoracic Cancer1759-77061759-77142023-12-0114353445345210.1111/1759-7714.15137Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changesMasahide Saito0Takafumi Komiyama1Kan Marino2Shinichi Aoki3Tomoko Akita4Masaki Matsuda5Naoki Sano6Hidekazu Suzuki7Ueda Koji8Hikaru Nemoto9Hiroshi Onishi10Department of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanDepartment of Radiology University of Yamanashi Yamanashi JapanAbstract Background The purpose of this study was to compare the dosimetric characteristics of five different treatment planning techniques for locally advanced non‐small cell lung cancer (LA‐NSCLC) with sequential plan changes. Methods A total of 13 stage III NSCLC patients were enrolled in this study. These patients had both computed tomography (CT) images for initial and boost treatment plans. The latter CT images were taken if tumor shrinkage was observed after 2 weeks of treatment. The prescription dose was 60 Gy/30 Fr (initial: 40 Gy/20 Fr, and boost: 20 Gy/10 Fr). Five techniques (forward‐planed 3‐dimensional conformal radiotherapy [F‐3DCRT] on both CT images, inverse‐planned 3DCRT [I‐3DCRT] on both CT images, volumetric modulated arc therapy [VMAT] on both CT images, F‐3DCRT on initial CT plus VMAT on boost CT [bVMAT], and hybrid of fixed intensity‐modulated radiotherapy [IMRT] beams and VMAT beams on both CT images [hybrid]) were recalculated for all patients. The accumulated doses between initial and boost plans were compared among all treatment techniques. Results The conformity indexes (CI) of the planning target volume (PTV) of the five planning techniques were 0.34 ± 0.10, 0.57 ± 0.10, 0.86 ± 0.08, 0.61 ± 0.12, and 0.83 ± 0.11 for F‐3DCRT, I‐3DCRT, VMAT, bVMAT, and hybrid, respectively. In the same manner, lung volumes receiving >20 Gy (V20Gy) were 21.05 ± 10.56%, 20.86 ± 6.45, 19.50 ± 7.38%, 19.98 ± 10.04%, and 17.74 ± 7.86%. There was significant improvement about CI and V20Gy for hybrid compared with F‐3DCRT (p < 0.05). Conclusion The IMRT/VMAT hybrid technique for LA‐NSCLC patients improved target CI and reduced lung doses. Furthermore, if IMRT was not available initially, starting with 3DCRT might be beneficial as demonstrated in the bVMAT procedure of this study.https://doi.org/10.1111/1759-7714.151373DCRTIMRTlung cancerradiotherapyVMAT |
| spellingShingle | Masahide Saito Takafumi Komiyama Kan Marino Shinichi Aoki Tomoko Akita Masaki Matsuda Naoki Sano Hidekazu Suzuki Ueda Koji Hikaru Nemoto Hiroshi Onishi Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changes Thoracic Cancer 3DCRT IMRT lung cancer radiotherapy VMAT |
| title | Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changes |
| title_full | Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changes |
| title_fullStr | Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changes |
| title_full_unstemmed | Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changes |
| title_short | Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non‐small cell lung cancer with sequential plan changes |
| title_sort | dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non small cell lung cancer with sequential plan changes |
| topic | 3DCRT IMRT lung cancer radiotherapy VMAT |
| url | https://doi.org/10.1111/1759-7714.15137 |
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