Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and Hops
Experimental and clinical studies evidenced the health effects of moderate consumption of beer, mainly due to the presence of bioactive compounds, such as polyphenols, vitamins, or fibers. To exploit the potential beneficial effect on health and in disease prevention of these compounds, a new bevera...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/1/29 |
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| author | Idolo Tedesco Carmela Spagnuolo Stefania Bilotto Angelo A. Izzo Francesca Borrelli Daniela Rigano Maria Russo Fabrizio Tarricone Gian Luigi Russo |
| author_facet | Idolo Tedesco Carmela Spagnuolo Stefania Bilotto Angelo A. Izzo Francesca Borrelli Daniela Rigano Maria Russo Fabrizio Tarricone Gian Luigi Russo |
| author_sort | Idolo Tedesco |
| collection | DOAJ |
| description | Experimental and clinical studies evidenced the health effects of moderate consumption of beer, mainly due to the presence of bioactive compounds, such as polyphenols, vitamins, or fibers. To exploit the potential beneficial effect on health and in disease prevention of these compounds, a new beverage based on barley malts and hops named Aliophen<sup>®</sup> has been designed, through a patented production process, with a high total polyphenolic amount compared to alcohol-free beer and similar to the one present in light and dark beers. In the present study, the antioxidant activity of Aliophen<sup>®</sup> against low-density lipoprotein (LDL) oxidation and its ability to protect erythrocytes from hemolysis have been characterized. Moreover, the chemopreventive effect of Aliophen<sup>®</sup> against colon cancer has been assessed, employing a mouse model of chemically induced carcinogenesis using azoxymethane (AOM). Data obtained showed that Aliophen at a low dose (3 mg/kg) inhibited the formation of preneoplastic lesions, polyps, and tumors. At higher doses (300 mg/kg) the protective effect was measured in the first phase of the onset of cancer. The antioxidant properties of Aliophen<sup>®</sup> were also observed in AOM-treated mice where it increased the serum antioxidant capacity. Based on the data presented, Aliophen<sup>®</sup> can exert promising health effects, including an anticancer capacity presumably associated with its antioxidant properties. |
| first_indexed | 2024-03-10T13:40:40Z |
| format | Article |
| id | doaj.art-73824e7994c5407cbabceceed84ab7de |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T13:40:40Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-73824e7994c5407cbabceceed84ab7de2023-11-21T03:04:37ZengMDPI AGAntioxidants2076-39212020-12-011012910.3390/antiox10010029Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and HopsIdolo Tedesco0Carmela Spagnuolo1Stefania Bilotto2Angelo A. Izzo3Francesca Borrelli4Daniela Rigano5Maria Russo6Fabrizio Tarricone7Gian Luigi Russo8National Research Council, Institute of Food Sciences, 83100 Avellino, ItalyNational Research Council, Institute of Food Sciences, 83100 Avellino, ItalyNational Research Council, Institute of Food Sciences, 83100 Avellino, ItalyDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, ItalyNational Research Council, Institute of Food Sciences, 83100 Avellino, ItalyALIOPHARM S.r.l., 20124 Milan, ItalyNational Research Council, Institute of Food Sciences, 83100 Avellino, ItalyExperimental and clinical studies evidenced the health effects of moderate consumption of beer, mainly due to the presence of bioactive compounds, such as polyphenols, vitamins, or fibers. To exploit the potential beneficial effect on health and in disease prevention of these compounds, a new beverage based on barley malts and hops named Aliophen<sup>®</sup> has been designed, through a patented production process, with a high total polyphenolic amount compared to alcohol-free beer and similar to the one present in light and dark beers. In the present study, the antioxidant activity of Aliophen<sup>®</sup> against low-density lipoprotein (LDL) oxidation and its ability to protect erythrocytes from hemolysis have been characterized. Moreover, the chemopreventive effect of Aliophen<sup>®</sup> against colon cancer has been assessed, employing a mouse model of chemically induced carcinogenesis using azoxymethane (AOM). Data obtained showed that Aliophen at a low dose (3 mg/kg) inhibited the formation of preneoplastic lesions, polyps, and tumors. At higher doses (300 mg/kg) the protective effect was measured in the first phase of the onset of cancer. The antioxidant properties of Aliophen<sup>®</sup> were also observed in AOM-treated mice where it increased the serum antioxidant capacity. Based on the data presented, Aliophen<sup>®</sup> can exert promising health effects, including an anticancer capacity presumably associated with its antioxidant properties.https://www.mdpi.com/2076-3921/10/1/29alcohol-free beerpolyphenolsantioxidantcolon cancerchemoprevention |
| spellingShingle | Idolo Tedesco Carmela Spagnuolo Stefania Bilotto Angelo A. Izzo Francesca Borrelli Daniela Rigano Maria Russo Fabrizio Tarricone Gian Luigi Russo Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and Hops Antioxidants alcohol-free beer polyphenols antioxidant colon cancer chemoprevention |
| title | Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and Hops |
| title_full | Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and Hops |
| title_fullStr | Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and Hops |
| title_full_unstemmed | Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and Hops |
| title_short | Antioxidant and Chemopreventive Effect of Aliophen<sup>®</sup> Formulation Based on Malts and Hops |
| title_sort | antioxidant and chemopreventive effect of aliophen sup r sup formulation based on malts and hops |
| topic | alcohol-free beer polyphenols antioxidant colon cancer chemoprevention |
| url | https://www.mdpi.com/2076-3921/10/1/29 |
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