The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels
To create functional tissue engineering scaffolds, biomaterials should mimic the native extracellular matrix of the tissue to be regenerated. Simultaneously, the survival and functionality of stem cells should also be enhanced to promote tissue organisation and repair. Hydrogels, but in particular,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/12/4616 |
| _version_ | 1827736265430138880 |
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| author | Anna J. Morwood Ikhlas A. El-Karim Susan A. Clarke Fionnuala T. Lundy |
| author_facet | Anna J. Morwood Ikhlas A. El-Karim Susan A. Clarke Fionnuala T. Lundy |
| author_sort | Anna J. Morwood |
| collection | DOAJ |
| description | To create functional tissue engineering scaffolds, biomaterials should mimic the native extracellular matrix of the tissue to be regenerated. Simultaneously, the survival and functionality of stem cells should also be enhanced to promote tissue organisation and repair. Hydrogels, but in particular, peptide hydrogels, are an emerging class of biocompatible scaffolds which act as promising self-assembling biomaterials for tissue engineering and regenerative therapies, ranging from articular cartilage regeneration at joint defects, to regenerative spinal cord injury following trauma. To enhance hydrogel biocompatibility, it has become imperative to consider the native microenvironment of the site for regeneration, where the use of functionalised hydrogels with extracellular matrix adhesion motifs has become a novel, emerging theme. In this review, we will introduce hydrogels in the context of tissue engineering, provide insight into the complexity of the extracellular matrix, investigate specific adhesion motifs that have been used to generate functionalised hydrogels and outline their potential applications in a regenerative medicine setting. It is anticipated that by conducting this review, we will provide greater insight into functionalised hydrogels, which may help translate their use towards therapeutic roles. |
| first_indexed | 2024-03-11T02:07:16Z |
| format | Article |
| id | doaj.art-7382930e70de4c87b58d41dbb17065bb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T02:07:16Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7382930e70de4c87b58d41dbb17065bb2023-11-18T11:48:02ZengMDPI AGMolecules1420-30492023-06-012812461610.3390/molecules28124616The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised HydrogelsAnna J. Morwood0Ikhlas A. El-Karim1Susan A. Clarke2Fionnuala T. Lundy3Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKMedical Biology Centre, School of Nursing and Midwifery, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKTo create functional tissue engineering scaffolds, biomaterials should mimic the native extracellular matrix of the tissue to be regenerated. Simultaneously, the survival and functionality of stem cells should also be enhanced to promote tissue organisation and repair. Hydrogels, but in particular, peptide hydrogels, are an emerging class of biocompatible scaffolds which act as promising self-assembling biomaterials for tissue engineering and regenerative therapies, ranging from articular cartilage regeneration at joint defects, to regenerative spinal cord injury following trauma. To enhance hydrogel biocompatibility, it has become imperative to consider the native microenvironment of the site for regeneration, where the use of functionalised hydrogels with extracellular matrix adhesion motifs has become a novel, emerging theme. In this review, we will introduce hydrogels in the context of tissue engineering, provide insight into the complexity of the extracellular matrix, investigate specific adhesion motifs that have been used to generate functionalised hydrogels and outline their potential applications in a regenerative medicine setting. It is anticipated that by conducting this review, we will provide greater insight into functionalised hydrogels, which may help translate their use towards therapeutic roles.https://www.mdpi.com/1420-3049/28/12/4616biocompatibilitytissue engineeringbiomimetic peptidedental pulpbonelung |
| spellingShingle | Anna J. Morwood Ikhlas A. El-Karim Susan A. Clarke Fionnuala T. Lundy The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels Molecules biocompatibility tissue engineering biomimetic peptide dental pulp bone lung |
| title | The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels |
| title_full | The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels |
| title_fullStr | The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels |
| title_full_unstemmed | The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels |
| title_short | The Role of Extracellular Matrix (ECM) Adhesion Motifs in Functionalised Hydrogels |
| title_sort | role of extracellular matrix ecm adhesion motifs in functionalised hydrogels |
| topic | biocompatibility tissue engineering biomimetic peptide dental pulp bone lung |
| url | https://www.mdpi.com/1420-3049/28/12/4616 |
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