The Role of Long Non-Coding RNAs in Osteosarcoma
Long non-coding RNAs (lncRNAs) constitute non-protein coding transcripts with a size > than 200 nucleotides. They are involved in many cellular processes, such as chromatin remodelling, transcription, and gene expression. They play a role in the development, progression, and invasion of many...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2311-553X/4/1/7 |
| _version_ | 1819077968116318208 |
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| author | Maria Anna Smolle Martin Pichler |
| author_facet | Maria Anna Smolle Martin Pichler |
| author_sort | Maria Anna Smolle |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) constitute non-protein coding transcripts with a size > than 200 nucleotides. They are involved in many cellular processes, such as chromatin remodelling, transcription, and gene expression. They play a role in the development, progression, and invasion of many human cancers, including osteosarcoma. This rare tumor entity predominantly arises in children and young adults. Treatment consists of polychemotherapy and surgical resection, increasing survival rates up to 60%. In the present review, the role of lncRNAs with prognostic, predictive, therapeutic, and diagnostic significance in osteosarcoma is discussed. Moreover, their potential application in clinical practice is highlighted. |
| first_indexed | 2024-12-21T19:05:37Z |
| format | Article |
| id | doaj.art-738362b50926459abcb03d3c5c40c5a8 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-12-21T19:05:37Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-738362b50926459abcb03d3c5c40c5a82022-12-21T18:53:21ZengMDPI AGNon-Coding RNA2311-553X2018-03-0141710.3390/ncrna4010007ncrna4010007The Role of Long Non-Coding RNAs in OsteosarcomaMaria Anna Smolle0Martin Pichler1Department of Orthopaedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036 Graz, AustriaDivision of Clinical Oncology, Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, AustriaLong non-coding RNAs (lncRNAs) constitute non-protein coding transcripts with a size > than 200 nucleotides. They are involved in many cellular processes, such as chromatin remodelling, transcription, and gene expression. They play a role in the development, progression, and invasion of many human cancers, including osteosarcoma. This rare tumor entity predominantly arises in children and young adults. Treatment consists of polychemotherapy and surgical resection, increasing survival rates up to 60%. In the present review, the role of lncRNAs with prognostic, predictive, therapeutic, and diagnostic significance in osteosarcoma is discussed. Moreover, their potential application in clinical practice is highlighted.http://www.mdpi.com/2311-553X/4/1/7lncRNAosteosarcomapathogenesis |
| spellingShingle | Maria Anna Smolle Martin Pichler The Role of Long Non-Coding RNAs in Osteosarcoma Non-Coding RNA lncRNA osteosarcoma pathogenesis |
| title | The Role of Long Non-Coding RNAs in Osteosarcoma |
| title_full | The Role of Long Non-Coding RNAs in Osteosarcoma |
| title_fullStr | The Role of Long Non-Coding RNAs in Osteosarcoma |
| title_full_unstemmed | The Role of Long Non-Coding RNAs in Osteosarcoma |
| title_short | The Role of Long Non-Coding RNAs in Osteosarcoma |
| title_sort | role of long non coding rnas in osteosarcoma |
| topic | lncRNA osteosarcoma pathogenesis |
| url | http://www.mdpi.com/2311-553X/4/1/7 |
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