Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer
Background and objective Tissue inhibitor of metalloproteinase-3 (TIMP-3) can regulate tumor infiltration and metastasis through multiple channels and is likely associated with mutant-type p53 (mtp53). This study detected the expressions of TIMP-3 and mtp53 in non-small cell lung cancer (NSCLC) and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2012-04-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.04.02 |
| _version_ | 1818022416089088000 |
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| author | Shangfu ZHANG Jie LI Jia GUO Hong YANG |
| author_facet | Shangfu ZHANG Jie LI Jia GUO Hong YANG |
| author_sort | Shangfu ZHANG |
| collection | DOAJ |
| description | Background and objective Tissue inhibitor of metalloproteinase-3 (TIMP-3) can regulate tumor infiltration and metastasis through multiple channels and is likely associated with mutant-type p53 (mtp53). This study detected the expressions of TIMP-3 and mtp53 in non-small cell lung cancer (NSCLC) and lymph node metastasis using tissue microarray and evaluated their significance. Methods TIMP-3 and mtp53 expressions were detected in 288 cases of NSCLC (NSCLC group), 106 cases of metastatic carcinoma in lymph nodes (metastasis group), and 24 cases of benign lesions in the bronchial mucosa epithelium (control group) by immunohistochemical staining (LSAB and Elivision). Results The expression of TIMP-3 in the NSCLC and metastasis groups was lower than that in the control group (P<0.001), but the reverse was true for the expression of mtp53 (P<0.001). TIMP-3 and mtp53 expressions differed between NSCLC with (P=0.015) and without (P=0.030) lymph node metastasis. TIMP-3 expression correlated with NSCLC grade (P=0.030), whereas mtp53 expression correlated with TNM stage (P=0.016) and NSCLC histological type (P=0.004). Moreover, the expressions of TIMP-3 and mtp53 were negative in NSCLC cases (P=0.008) and correlated with patient survival (P=0.011 and P=0.003, respectively). Conclusion Low expression of TIMP-3 and high expression of mtp53 in NSCLC can promote tumor metastasis and inhibit each other. TIMP-3 and mtp53 are promising targets for studying the metastatic mechanism of NSCLC. |
| first_indexed | 2024-04-14T08:31:13Z |
| format | Article |
| id | doaj.art-73847e38d3274aa9a57e8a04e702cd49 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-14T08:31:13Z |
| publishDate | 2012-04-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-73847e38d3274aa9a57e8a04e702cd492022-12-22T02:03:54ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872012-04-0115420220710.3779/j.issn.1009-3419.2012.04.02Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung CancerShangfu ZHANGJie LIJia GUOHong YANGBackground and objective Tissue inhibitor of metalloproteinase-3 (TIMP-3) can regulate tumor infiltration and metastasis through multiple channels and is likely associated with mutant-type p53 (mtp53). This study detected the expressions of TIMP-3 and mtp53 in non-small cell lung cancer (NSCLC) and lymph node metastasis using tissue microarray and evaluated their significance. Methods TIMP-3 and mtp53 expressions were detected in 288 cases of NSCLC (NSCLC group), 106 cases of metastatic carcinoma in lymph nodes (metastasis group), and 24 cases of benign lesions in the bronchial mucosa epithelium (control group) by immunohistochemical staining (LSAB and Elivision). Results The expression of TIMP-3 in the NSCLC and metastasis groups was lower than that in the control group (P<0.001), but the reverse was true for the expression of mtp53 (P<0.001). TIMP-3 and mtp53 expressions differed between NSCLC with (P=0.015) and without (P=0.030) lymph node metastasis. TIMP-3 expression correlated with NSCLC grade (P=0.030), whereas mtp53 expression correlated with TNM stage (P=0.016) and NSCLC histological type (P=0.004). Moreover, the expressions of TIMP-3 and mtp53 were negative in NSCLC cases (P=0.008) and correlated with patient survival (P=0.011 and P=0.003, respectively). Conclusion Low expression of TIMP-3 and high expression of mtp53 in NSCLC can promote tumor metastasis and inhibit each other. TIMP-3 and mtp53 are promising targets for studying the metastatic mechanism of NSCLC.http://dx.doi.org/10.3779/j.issn.1009-3419.2012.04.02Lung neoplasmsTIMP-3mtp53Tissue microarrayPrognosis |
| spellingShingle | Shangfu ZHANG Jie LI Jia GUO Hong YANG Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms TIMP-3 mtp53 Tissue microarray Prognosis |
| title | Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer |
| title_full | Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer |
| title_fullStr | Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer |
| title_full_unstemmed | Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer |
| title_short | Expressions and Significance of TIMP-3 and mtp53 in Non-small Cell Lung Cancer |
| title_sort | expressions and significance of timp 3 and mtp53 in non small cell lung cancer |
| topic | Lung neoplasms TIMP-3 mtp53 Tissue microarray Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2012.04.02 |
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