The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in Rats
Purpose: To assess the beneficial effect of different fractions of Cynodondactylon (C. dactylon) on ethylene glycol-induced kidney calculi in rats. Materials and Methods: Male Wistar rats were randomly divided intocontrol, ethylene glycol, curative, and preventive groups. The control group received...
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| Format: | Article |
| Language: | English |
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Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences
2011-09-01
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| Series: | Urology Journal |
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| Online Access: | http://www.urologyjournal.org/index.php/uj/article/view/1129/587 |
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| author | Abolfazl Khajavi Rad Mousa-Al-Reza Hadjzadeh Ziba Rajaei Nema Mohammadian Saleh Valiollahi Mehdi Sonei |
| author_facet | Abolfazl Khajavi Rad Mousa-Al-Reza Hadjzadeh Ziba Rajaei Nema Mohammadian Saleh Valiollahi Mehdi Sonei |
| author_sort | Abolfazl Khajavi Rad |
| collection | DOAJ |
| description | Purpose: To assess the beneficial effect of different fractions of Cynodondactylon (C. dactylon) on ethylene glycol-induced kidney calculi in rats. Materials and Methods: Male Wistar rats were randomly divided intocontrol, ethylene glycol, curative, and preventive groups. The control group received tap drinking water for 35 days. Ethylene glycol, curative, and preventive groups received 1% ethylene glycol for induction of calcium oxalate (CaOx) calculus formation. Preventive and curative subjects also received different fractions of C. dactylon extract in drinking water at 12.8mg/kg, since day 0 and day 14, respectively. After 35 days, the kidneys were removed and examined for histopathological findings and counting the CaOx deposits in 50 microscopic fields. Results: In curative protocol, treatment of rats with C. dactylonN-butanol fraction and N-butanol phase remnant significantly reduced the number of the kidney CaOx deposits compared to ethylene glycol group. In preventive protocol, treatment of rats with C. dactylonethyl acetate fraction significantly decreased the number of CaOx deposits compared to ethylene glycol group. Conclusion: Fractions of C. dactylon showed a beneficial effect on preventing and eliminating CaOx deposition in the rat kidney. These results provide ascientific rational for preventive and treatment roles of C. dactylonin human kidney stone disease. |
| first_indexed | 2024-12-20T01:23:09Z |
| format | Article |
| id | doaj.art-7384be7536bf4a0ea04c3e6cc3ac7402 |
| institution | Directory Open Access Journal |
| issn | 1735-1308 1735-546X |
| language | English |
| last_indexed | 2024-12-20T01:23:09Z |
| publishDate | 2011-09-01 |
| publisher | Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Urology Journal |
| spelling | doaj.art-7384be7536bf4a0ea04c3e6cc3ac74022022-12-21T19:58:21ZengUrology and Nephrology Research Center, Shahid Beheshti University of Medical SciencesUrology Journal1735-13081735-546X2011-09-0183179184The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in RatsAbolfazl Khajavi RadMousa-Al-Reza HadjzadehZiba RajaeiNema MohammadianSaleh ValiollahiMehdi SoneiPurpose: To assess the beneficial effect of different fractions of Cynodondactylon (C. dactylon) on ethylene glycol-induced kidney calculi in rats. Materials and Methods: Male Wistar rats were randomly divided intocontrol, ethylene glycol, curative, and preventive groups. The control group received tap drinking water for 35 days. Ethylene glycol, curative, and preventive groups received 1% ethylene glycol for induction of calcium oxalate (CaOx) calculus formation. Preventive and curative subjects also received different fractions of C. dactylon extract in drinking water at 12.8mg/kg, since day 0 and day 14, respectively. After 35 days, the kidneys were removed and examined for histopathological findings and counting the CaOx deposits in 50 microscopic fields. Results: In curative protocol, treatment of rats with C. dactylonN-butanol fraction and N-butanol phase remnant significantly reduced the number of the kidney CaOx deposits compared to ethylene glycol group. In preventive protocol, treatment of rats with C. dactylonethyl acetate fraction significantly decreased the number of CaOx deposits compared to ethylene glycol group. Conclusion: Fractions of C. dactylon showed a beneficial effect on preventing and eliminating CaOx deposition in the rat kidney. These results provide ascientific rational for preventive and treatment roles of C. dactylonin human kidney stone disease.http://www.urologyjournal.org/index.php/uj/article/view/1129/587Cynodon dactylonkidney calculiethylene glycolcalcium oxalate |
| spellingShingle | Abolfazl Khajavi Rad Mousa-Al-Reza Hadjzadeh Ziba Rajaei Nema Mohammadian Saleh Valiollahi Mehdi Sonei The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in Rats Urology Journal Cynodon dactylon kidney calculi ethylene glycol calcium oxalate |
| title | The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in Rats |
| title_full | The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in Rats |
| title_fullStr | The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in Rats |
| title_full_unstemmed | The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in Rats |
| title_short | The Beneficial Effect of CynodonDactylonFractionson Ethylene Glycol-Induced Kidney Calculi in Rats |
| title_sort | beneficial effect of cynodondactylonfractionson ethylene glycol induced kidney calculi in rats |
| topic | Cynodon dactylon kidney calculi ethylene glycol calcium oxalate |
| url | http://www.urologyjournal.org/index.php/uj/article/view/1129/587 |
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